临床PI
吴炅 教授
教授,博士生导师
E-mail: wujiong1122@vip.sina.com
 

  1993年与1998年分别获复旦大学上海医学院 (原上海医科大学) 医学学士学位和肿瘤学博士学位。1998年获UICC ICRETT资助赴美国加州大学洛杉矶分校,研究乳腺肌上皮细胞旁分泌对乳腺癌生长与浸润的作用。2004年7月赴美国Texas, Houston, M.D. Anderson肿瘤中心整形外科进修一期乳房重建手术。2008年起任复旦大学肿瘤医院乳腺外科主任医师,现任复旦大学附属肿瘤医院业务副院长,中国抗癌协会乳腺癌专业委员会副主任委员,上海市抗癌协会乳腺癌分会主任委员,上海市医学会肿瘤靶分子专科分会副主任委员,教授,博士生导师。2004年以第三完成人获国家科技进步二等奖(乳腺癌的临床和基础研究),作为第三完成人于2002年和2003年2次获得上海市科技进步二等奖;作为主要参与者2次获得上海市科技进步三等奖;先后获上海市卫生局首批"医苑新星"、上海市卫生局先进工作者、复旦大学"世纪之星"、上海市科技启明星、上海市教委曙光计划等人才基金资助。在国内外刊物上共发表论文200余篇,以第一作者及通讯作者身份发表SCI论文60余篇。参与撰写《现代乳腺肿瘤学进展》(2002年)、《乳腺肿瘤学》(2005年)等。目前正承担国家重点基础研究发展计划(973计划)子课题、上海市卫生系统优秀学科带头人计划、国家自然科学基金面上项目、上海市科委国际合作项目(政府间)等项目研究。


研究领域:

  致力于开展基因标志物在乳腺癌早期诊断、预后及疗效预测中的价值等基础研究;积极应用、推广新的外科技术,诸如前哨淋巴结活检、乳房重建手术,丰富及完善肿瘤-整复领域临床研究。

研究团队:

  研究助理:迟亚云、薛静彦
  研究生:陈嘉健、杨犇龙、黄乃思、郭亮、全晨莲、司婧、马林晓曦

代表性论著:

  1. Xue J#, Chi Y#, Chen Y, Huang S, Ye X, Niu J, Wang W, Pfeffer L M, Shao Z-M, Wu Z-H*, Wu J*. MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity. Oncogene, 2016; 35(4):448-458.
  2. Chi Yayun#, Yao Ling, Hu Xin, Huang Sheng, Huang Naisi, Li Shan, Shao Zhiming, Wu Jiong*. The BMP inhibitor DAND5 in serum predicts poor survival in breast cancer. Oncotarget, 2016 Feb 19. doi: 10.18632/oncotarget.7498. [Epub ahead of print]
  3. Lou Feifei#, Sun Zhirong, Huang Naisi, Hu Zhen, Cao Ayong, Shen Zhenzhou, Shao Zhimin, Yu Peirong, Miao Changhong, Wu Jiong*. Epidural Combined with General Anesthesia versus General Anesthesia Alone in Patients Undergoing Free Flap Breast Reconstruction. Plastic and Reconstructive Surgery, 2016; 137(3):502e-509e.
  4. Niu, J#, Xue A, Chi Y, Xue J, Wang W, Zhao Z, Fan M, Yang CH, Shao Z-M, Pfeffer L M, Wu J*, Wu Z-H*. Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer. Oncogene, 2016 Mar 10; 35(10):1302-13.
  5. Chen Jia-ying#, Chen Jia-jian, Xue Jing-yan, Chen Ying, Liu Guang-yu, Han Qi-xia, Yang Wen-tao, Shen Zhen-zhou, Shao Zhi-min, Wu Jiong*. Predicting Non-sentinel Lymph Node Metastasis in a Chinese Breast Cancer Population with 1-2 Positive Sentinel Nodes: Development and Assessment of a New Predictive Nomogram. World J Surg, 2015; 39(12):2919-2927.
  6. Huang Naisi#,Chen Jiajian, Xue Jingyan, Yu Baohua, Chen Yanqiong, Yang Wentao, Shao Zhimin, Wu Jiong*. Breast Sclerosing Adenosis and Accompanying Malignancies: A Clinicopathological and Imaging Study in a Chinese Population. Medicine (Baltimore), 2015; 94(49):e2298-e2298.
  7. Huang Nai-Si#, Wu Jiong*. Nipple-sparing Mastectomy in Breast Cancer: From an Oncologic Safety Perspective. Chin Med J (Engl), 2015; 128(16):2256-2261.
  8. Jia-jian Chen#, Nai-si Huang#, Jing-yan Xue, Ben-long Yang, Guang-yu Liu, Gen-hong Di, Zhi-min Shao, Jiong Wu*. Current Status of Breast Reconstruction in Southern China: A 15 Year, Single Institutional Experience of 20,551 Breast Cancer Patients. Medicine (Baltimore), 2015; 94(34):e1399-e1399.
  9. Huang Xiaoyan#, Dugo Matteo, Callari Maurizio, Sandri Marco, De Cecco Loris, Valeri Barbara, Carcangiu Maria Luisa, Xue Jingyan, Bi Rui, Veneroni Silvia, Daidone Maria Grazia, Menard Sylvie, Tagliabue Elda, Shao Zhimin, Wu Jiong*, Orlandi, Rosaria*. Molecular portrait of breast cancer in China reveals comprehensive transcriptomic likeness to Caucasian breast cancer and low prevalence of luminal A subtype. Cancer Med, 2015; 4(7):1016-1030.
  10. Jiang Hong-Lin#, Sun He-Fen, Gao Shui-Ping, Li Liang-Dong, Hu Xin, Wu Jiong*, Jin Wei*. Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-beta/SMAD signaling. Oncotarget, 2015; 6(18):16352-16365.
  11. Naisi Huang#, Mengying Liu, Peirong Yu, Jiong Wu*. Antibiotic prophylaxis in prosthesis-based mammoplasty: A systematic review. International Journal of Surgery, 2015; 15:31-37.
  12. Chen, Ying#, Shen Zhenzhou, Shao Zhimin, Yu Peirong, Wu Jiong*. Free Flap Monitoring Using Near-Infrared Spectroscopy: A Systemic Review. Annals of Plastic Surgery, 2015; 1(1).
  13. Chen Jia-jian#, Huang Nai-si, Xue Jing-yan, Quan Chen-lian,Tan Yu-long, Liu Guang-yu, Shao Zhi-min, Wu Jiong*. Surgical management for early-stage bilateral breast cancer patients in China. PLos One, 2015; 10(4):e0122692-e0122692.
  14. Chi Yayun#, Huang Sheng, Liu Mengying, Guo Liang, Shen Xuxia, Wu Jiong*. Cyclin D3 predicts disease-free survival in breast cancer. Cancer Cell Int, 2015; 15:89-89.
  15. Chi Yayun#, Huang Sheng, Peng Haojie,Liu Mengying, Zhao Jun, Shao Zhiming, Wu Jiong*. Critical role of CDK11(p58) in human breast cancer growth and angiogenesis. BMC Cancer, 2015; 15:701-701.
  16. Yang Benlong#, Li Lin, Yan Wenhui, Chen Jiaying, Chen Ying, Hu Zhen, Liu Guangyu, Shen Zhenzhou, Shao Zhimin, Wu Jiong*. The Type of Breast Reconstruction May Not Influence Patient Satisfaction in the Chinese Population: A Single Institutional Experience. PLoS One, 2015; 10(11):e0142900-e0142900.
  17. Huang Sheng#, Kou Binquan#, Chi Yayun#, Xi Yan, Cao Yi, Cui Wenli, Hu Xin, Shao Zhimin, Guo Han, Fu Yanan, Xiao Tiqiao, Sun Jianqi, Zhao Jun, Wang Yujie, Wu Jiong*. In-line phase-contrast and grating-based phase-contrast synchrotron imaging study of brain micrometastasis of breast cancer. Scientific Reports, 2015; 5:9418-9418.
  18. Hu XC, Zhang J, Xu BH, Cai L, Ragaz J, Wang ZH, Wang BY, Teng YE, Tong ZS, Pan YY, Yin YM, Wu CP, Jiang ZF, Wang XJ, Lou GY, Liu DG, Feng JF, Luo JF, Sun K, Gu YJ, Wu J, Shao ZM. Cisplatin plus gemcitabine versus paclitaxel plus gemcitabine as first-line therapy for metastatic triple-negative breast cancer (CBCSG006): a randomised, open-label, multicentre, phase 3 trial. Lancet Oncol, 2015 Apr; 16(4):436-46.
  19. Xue Jingyan#, Niu Jixiao, Wu Jiong*, Wu Zhao-Hui*. MicroRNAs in cancer therapeutic response: Friend and foe. World Journal of Clinical Oncology, 2014; 5(4):730-743.
  20. Li Lin#, Chen Ying, Chen Jiaying, Chen Jiajian, Yang Benlong, Li Junjie, Huang Xiaoyan, Shen Zhenzhou, Shao Zhimin, Yu Peirong, Wu Jiong*. Adjuvant chemotherapy increases the prevalence of fat necrosis in immediate free abdominal flap breast reconstruction. J Plast Reconstr Aesthet Surg, 2014; 67(4):461-467.
  21. Chen Jia-Jian#, Wang Yan, Xue Jing-Yan, Chen Ying, Chen Ya-Ling, Xiao Qin, Yang Wen-Tao, Shao Zhi-Min, Wu Jiong*. A clinicopathological study of early-stage synchronous bilateral breast cancer: a retrospective evaluation and prospective validation of potential risk factors. PLoS One, 2014; 9(4):e95185-e95185.
  22. Chi Yayun#, Huang Sheng, Yuan Lin, Liu Mengying, Huang Naisi, Zhou Shuling, Zhou Bingqing, Wu Jiong*. Role of BC040587 as a predictor of poor outcome in breast cancer. Cancer Cell International, 2014; 14(1):123-123.
  23. Chi Yayun#, Huang Sheng, Wang Lei, Zhou Ruoji, Wang Lisha, Xiao Xiuying, Li Dali, Cai, Ying, Zhou Xiaoyan, Wu Jiong*. CDK11p58 inhibits ERalpha-positive breast cancer invasion by targeting integrin beta3 via the repression of ERalpha signaling. BMC Cancer, 2014; 14:577-577.
  24. Fei Fei#, Chen Canming, Xue Jingyan, Di Gen-Hong, Lu Jin-Song, Liu Guang-Yu, Shao Zhi-Ming, Wu Jiong*. Efficacy and safety of docetaxel combined with oxaliplatin as a neoadjuvant chemotherapy regimen for Chinese triple-negative local advanced breast cancer patients. A prospective, open, and unicentric Phase II clinical trial. Am J Clin Oncol, 2013; 36(6):545-551.
  25. Niu Jixiao#, Shi Yuling, Xue Jingyan, Miao Ruidong, Huang Shengping, Wang Tianyi, Wu Jiong, Fu Mingui, Wu Zhao-Hui. USP10 inhibits genotoxic NF-kappaB activation by MCPIP1-facilitated deubiquitination of NEMO. The EMBO Journal, 2013; 32(24):3206-3219.
  26. .Chen Y Z#, Xue J Y#,Chen C M, Yang B L, Xu Q H, Wu F, Liu F, Ye X, Meng X, Liu G Y, Shen Z Z, Shao Z M, Wu J*. PAR signaling pathway may be an important predictor of breast cancer response to neoadjuvant chemotherapy. Cancer Chemother Pharmacol, 2012; 70(5):637-644.
  27. Chen Jia-ying#, Chen Jia-jian, Yang Ben-long, Liu Zhe-bin, Huang Xiao-yan, Liu Guang-yu, Han Qi-xia, Yang Wen-tao, Shen Zhen-zhou, Shao Zhi-min, Wu J*. Predicting sentinel lymph node metastasis in a Chinese breast cancer population: assessment of an existing nomogram and a new predictive nomogram. Breast Cancer Res Treat, 2012; 135(3):839-848.
  28. Jin Wei#, Chen Bo-bin, Li Ji-yu, Zhu Hua, Huang Mark, Gu Sheng-mei, Wang Qiao-qiao, Chen Jia-ying, Yu Sanjian, Wu J*, Shao zhi-ming*. TIEG1 inhibits breast cancer invasion and metastasis by inhibition of epidermal growth factor receptor (EGFR) transcription and the EGFR signaling pathway. Mol Cell Biol, 2012; 32(1):50-63.
  29. Ding Jingxian#, Jin Wei, Chen Canming, Shao Zhiming, Wu Jiong*. Tumor associated macrophage x cancer cell hybrids may acquire cancer stem cell properties in breast cancer. PLoS One, 2012; 7(7):e41942-e41942.
  30. Gu Shengmei#, Chen Li, Hong Qi, Yan Tingting, Zhuang Zhigang, Wang Qiaoqiao, Jin Wei, Zhu Hua, Wu Jiong*. PEA3 activates CXCR4 transcription in MDA-MB-231 and MCF7 breast cancer cells. Acta Biochim Biophys Sin (Shanghai), 2011; 43(10):771-778.
  31. Chen Jia-Jian#, Wu Jiong*. Management strategy of early-stage breast cancer patients with a positive sentinel lymph node: With or without axillary lymph node dissection. Critical Reviews in Oncology/Hematology, 2011; 79(3):293-301.
  32. Yang Benlong, Tan Hongna, Chen Jiajian, Wang Shenping, Li Wentao, Peng Weijun, Han Qixia, Shen Zhenzhou, Shao Zhiming, Wu Jiong*. A Novel Technique for Localization of Sentinel Lymph Node in Breast Cancer Patients Based on Computed Tomographic Lymphography. BREAST JOURNAL, 2011; 17(4):431-433.
  33. Chen Yizuo#, Chen Canming, Yang Benlong, Xu Qinghua, Wu Fei, Liu Fang, Ye Xun, Meng Xia, Mougin Bruno, Liu Guangyu, Shen Zhenzhou, Shao Zhimin, Wu Jiong*. Estrogen receptor-related genes as an important panel of predictors for breast cancer response to neoadjuvant chemotherapy. Cancer Lett, 2011; 302(1):63-68.
  34. Chen Yi-Zuo#, Zhang Jia-Xin, Chen Jia-Jian, Liu Zhe-Bin, Huang Xiao-Yan, Cheng Jing Yi, Yang Wen-Tao, Shao Zhi-Min, Shen Zhen-Zhou, Wu Jiong*. Factors associated with the misdiagnosis of sentinel lymph nodes using touch imprint cytology for early stage breast cancer. Oncol Lett, 2011; 2(2):277-281.
  35. Chen Jia-jian#, Yang Ben-long, Chen Jia-ying, Zhang Jia-xin, Li Da-li, Xu Wei-ping, Xu Xiao-li, Yang Wen-tao, Shao Zhi-min, Shen Zhen-zhou, Wang Yong-sheng, Wu Jiong*. A prospective comparison of molecular assay and touch imprint cytology for intraoperative evaluation of sentinel lymph nodes. Chin Med J (Engl), 2011; 124(4):491-497.
  36. Yang Benlong#, Xu Qinghua, Wu Fei, Liu Fang, Ye Xun, Liu Guangyu, Shao Zhimin, Meng Xia, Mougin Bruno, Wu Jiong*. Using peripheral blood mRNA signature to distinguish between breast cancer and benign breast disease in non-conclusive mammography patients. Cancer Biol Ther, 2010; 10(12):1235-1239.
  37. Chen Jia-Jian#, Yang Ben-Long, Zhang Jia-Xin, Xu Wei-Ping, Shao Zhi-Min, Wu Jiong*. The evaluation and optimization of intraoperative touch imprint cytology for sentinel lymph nodes in early-stage breast cancer in China. World Journal of Surgery, 2010; 34(10):2325-2332.
  38. Chen J-J#, Huang X-Y, Liu Z-B, Chen T-W, Cheng J-Y, Yang W-T, Xu W-P, Shao Z-M, Shen Z-Z, Wu J*. Sentinel node biopsy and quality of life measures in a Chinese population. European Journal of Surgical Oncology, 2009; 35(9):921-927.
  39. Liu Zhe-Bin#, Wu Jiong, Ping Bo, Feng Li-Qing, Di Gen-Hong, Lu Jin-Song, Shen Kun-Wei, Shen Zhen-Zhou, Shao Zhi-Min. Basal cytokeratin expression in relation to immunohistochemical and clinical characterization in breast cancer patients with triple negative phenotype. Tumori, 2009; 95(1):53-62.
  40. Liu Zhe-Bin#, Liu Guang-Yu, Yang Wen-Tao, Di Gen-Hong, Lu Jin-Song, Shen Kun-Wei, Shen Zhen-Zhou, Shao Zhi-Min, Wu Jiong*. Triple-negative breast cancer types exhibit a distinct poor clinical characteristic in lymph node-negative Chinese patients. Oncology Reports, 2008; 20(4):987-994.
 
复旦大学肿瘤研究所 通讯地址: 东安路270号2号楼1312室 64175590-5312 Email:fuci2012@126.com
Copyright 2013 shca.org.cn All rights reserved. 复旦大学肿瘤研究所 版权所有