临床PI
吴炅 教授
教授,博士生导师
E-mail: wujiong1122@vip.sina.com
 

  1993年与1998年分别获复旦大学上海医学院 (原上海医科大学) 医学学士学位和肿瘤学博士学位。1998年获UICC ICRETT资助赴美国加州大学洛杉矶分校,研究乳腺肌上皮细胞旁分泌对乳腺癌生长与浸润的作用。2004年7月赴美国Texas, Houston, M.D. Anderson肿瘤中心整形外科进修一期乳房重建手术。2008年起任复旦大学肿瘤医院乳腺外科主任医师,现任复旦大学附属肿瘤医院业务副院长,中国抗癌协会乳腺癌专业委员会候任主任委员,上海市医学会肿瘤靶分子专科分会主任委员,教授,博士生导师。2004年以第三完成人获国家科技进步二等奖(乳腺癌的临床和基础研究),作为第三完成人于2002年和2003年2次获得上海市科技进步二等奖;作为主要参与者2次获得上海市科技进步三等奖;先后获上海市卫生局首批"医苑新星"、上海市卫生局先进工作者、复旦大学"世纪之星"、上海市科技启明星、上海市教委曙光计划等人才基金资助。在国内外刊物上共发表论文200余篇,以第一作者及通讯作者身份发表SCI论文70余篇。参与撰写《现代乳腺肿瘤学进展》(2002年)、《乳腺肿瘤学》(2005年)等。目前正承担国家重大慢病非传染性疾病防控研究课题、上海市科委优秀学术带头人计划、国家自然科学基金面上项目等研究。


研究领域:

  致力于开展基因标志物在乳腺癌早期诊断、预后及疗效预测中的价值等基础研究;积极应用、推广新的外科技术,诸如前哨淋巴结活检、乳房重建手术,丰富及完善肿瘤-整复领域临床研究。


研究团队:

  研究助理:迟亚云、薛静彦

  研究生:   杨犇龙、司婧、马林晓曦、苏永辉、郭瑢、王嘉、修秉虬、张琪、季玮儒


代表性论著:

  1. Sheng Huang#, Yayun Chi#, Yi Qin#, Ziliang Wang, Bingqiu Xiu, Yonghui Su, Rong Guo, Liang Guo, Hefen Sun, Chujia Zeng, Shuling Zhou, Xin Hu, Sheng Liu, Zhimin Shao, Zhaohui Wu, Wei Jin, Jiong Wu*. CAPG enhances breast cancer metastasis by competing with PRMT5 to modulate STC-1 transcription. Theranostics, 2018; 8(9): 2549-2564.
  2. Guo L, Chi Y, Xue J, Ma L, Shao Z, Wu J*. Phosphorylated eIF2α predicts disease-free survival in triple-negative breast cancer patients. Sci Rep, 2017; 7:44674.
  3. Huang NS, Quan CL, Mo M, Chen JJ, Yang BL, Huang XY, Wu J*. A prospective study of breast anthropomorphic measurements, volume and ptosis in 605 Asian patients with breast cancer or benign breast disease. PLoS One, 2017; 12(2):e0172122.
  4. Xue J#, Chi Y#, Chen Y, Huang S, Ye X, Niu J, Wang W, Pfeffer L M, Shao Z-M, Wu Z-H*, Wu J*. MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity. Oncogene, 2016; 35(4):448-458.
  5. Lou Feifei#, Sun Zhirong, Huang Naisi, Hu Zhen, Cao Ayong, Shen Zhenzhou, Shao Zhimin, Yu Peirong, Miao Changhong, Wu Jiong*. Epidural Combined with General Anesthesia versus General Anesthesia Alone in Patients Undergoing Free Flap Breast Reconstruction. Plastic and Reconstructive Surgery, 2016; 137(3):502e-509e.
  6. Niu, J#, Xue A, Chi Y, Xue J, Wang W, Zhao Z, Fan M, Yang CH, Shao Z-M, Pfeffer L M, Wu J*, Wu Z-H*. Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer. Oncogene, 2016 Mar 10; 35(10):1302-13.
  7. Chen Jia-ying#, Chen Jia-jian, Xue Jing-yan, Chen Ying, Liu Guang-yu, Han Qi-xia, Yang Wen-tao, Shen Zhen-zhou, Shao Zhi-min, Wu Jiong*. Predicting Non-sentinel Lymph Node Metastasis in a Chinese Breast Cancer Population with 1-2 Positive Sentinel Nodes: Development and Assessment of a New Predictive Nomogram. World J Surg, 2015; 39(12):2919-2927.
  8. Huang Naisi#,Chen Jiajian, Xue Jingyan, Yu Baohua, Chen Yanqiong, Yang Wentao, Shao Zhimin, Wu Jiong*. Breast Sclerosing Adenosis and Accompanying Malignancies: A Clinicopathological and Imaging Study in a Chinese Population. Medicine (Baltimore), 2015; 94(49):e2298-e2298.
  9. Huang Nai-Si#, Wu Jiong*. Nipple-sparing Mastectomy in Breast Cancer: From an Oncologic Safety Perspective. Chin Med J (Engl), 2015; 128(16):2256-2261.
  10. Jia-jian Chen#, Nai-si Huang#, Jing-yan Xue, Ben-long Yang, Guang-yu Liu, Gen-hong Di, Zhi-min Shao, Jiong Wu*. Current Status of Breast Reconstruction in Southern China: A 15 Year, Single Institutional Experience of 20,551 Breast Cancer Patients. Medicine (Baltimore), 2015; 94(34):e1399-e1399.
  11. Huang Xiaoyan#, Dugo Matteo, Callari Maurizio, Sandri Marco, De Cecco Loris, Valeri Barbara, Carcangiu Maria Luisa, Xue Jingyan, Bi Rui, Veneroni Silvia, Daidone Maria Grazia, Menard Sylvie, Tagliabue Elda, Shao Zhimin, Wu Jiong*, Orlandi, Rosaria*. Molecular portrait of breast cancer in China reveals comprehensive transcriptomic likeness to Caucasian breast cancer and low prevalence of luminal A subtype. Cancer Med, 2015; 4(7):1016-1030.
  12. Jiang Hong-Lin#, Sun He-Fen, Gao Shui-Ping, Li Liang-Dong, Hu Xin, Wu Jiong*, Jin Wei*. Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-beta/SMAD signaling. Oncotarget, 2015; 6(18):16352-16365.
  13. Naisi Huang#, Mengying Liu, Peirong Yu, Jiong Wu*. Antibiotic prophylaxis in prosthesis-based mammoplasty: A systematic review. International Journal of Surgery, 2015; 15:31-37.
  14. Chen, Ying#, Shen Zhenzhou, Shao Zhimin, Yu Peirong, Wu Jiong*. Free Flap Monitoring Using Near-Infrared Spectroscopy: A Systemic Review. Annals of Plastic Surgery, 2015; 1(1).
  15. Chen Jia-jian#, Huang Nai-si, Xue Jing-yan, Quan Chen-lian,Tan Yu-long, Liu Guang-yu, Shao Zhi-min, Wu Jiong*. Surgical management for early-stage bilateral breast cancer patients in China. PLos One, 2015; 10(4):e0122692-e0122692.
  16. Chi Yayun#, Huang Sheng, Liu Mengying, Guo Liang, Shen Xuxia, Wu Jiong*. Cyclin D3 predicts disease-free survival in breast cancer. Cancer Cell Int, 2015; 15:89-89.
  17. Chi Yayun#, Huang Sheng, Peng Haojie,Liu Mengying, Zhao Jun, Shao Zhiming, Wu Jiong*. Critical role of CDK11(p58) in human breast cancer growth and angiogenesis. BMC Cancer, 2015; 15:701-701.
  18. Huang Sheng#, Kou Binquan#, Chi Yayun#, Xi Yan, Cao Yi, Cui Wenli, Hu Xin, Shao Zhimin, Guo Han, Fu Yanan, Xiao Tiqiao, Sun Jianqi, Zhao Jun, Wang Yujie, Wu Jiong*. In-line phase-contrast and grating-based phase-contrast synchrotron imaging study of brain micrometastasis of breast cancer. Scientific Reports, 2015; 5:9418-9418.
  19. Hu XC, Zhang J, Xu BH, Cai L, Ragaz J, Wang ZH, Wang BY, Teng YE, Tong ZS, Pan YY, Yin YM, Wu CP, Jiang ZF, Wang XJ, Lou GY, Liu DG, Feng JF, Luo JF, Sun K, Gu YJ, Wu J, Shao ZM. Cisplatin plus gemcitabine versus paclitaxel plus gemcitabine as first-line therapy for metastatic triple-negative breast cancer (CBCSG006): a randomised, open-label, multicentre, phase 3 trial. Lancet Oncol, 2015 Apr; 16(4):436-46.
  20. Chi Yayun#, Huang Sheng, Wang Lei, Zhou Ruoji, Wang Lisha, Xiao Xiuying, Li Dali, Cai, Ying, Zhou Xiaoyan, Wu Jiong*. CDK11p58 inhibits ERalpha-positive breast cancer invasion by targeting integrin beta3 via the repression of ERalpha signaling. BMC Cancer, 2014; 14:577-577.
  21. Fei Fei#, Chen Canming, Xue Jingyan, Di Gen-Hong, Lu Jin-Song, Liu Guang-Yu, Shao Zhi-Ming, Wu Jiong*. Efficacy and safety of docetaxel combined with oxaliplatin as a neoadjuvant chemotherapy regimen for Chinese triple-negative local advanced breast cancer patients. A prospective, open, and unicentric Phase II clinical trial. Am J Clin Oncol, 2013; 36(6):545-551.
  22. Niu Jixiao#, Shi Yuling, Xue Jingyan, Miao Ruidong, Huang Shengping, Wang Tianyi, Wu Jiong, Fu Mingui, Wu Zhao-Hui. USP10 inhibits genotoxic NF-kappaB activation by MCPIP1-facilitated deubiquitination of NEMO. The EMBO Journal, 2013; 32(24):3206-3219.
 
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