临床PI
叶定伟 教授
教授,博士生导师
E-mail: Dwyeli@163.com
 

  叶定伟教授,复旦大学附属肿瘤医院副院长、中国抗癌协会泌尿肿瘤专业委员会候任主任委员、中国临床肿瘤学会肾癌专家委员会副主任委员、上海市泌尿外科学会副主任委员、NCCN肾癌诊治指南中国版编写组副组长、NCCN前列腺癌和膀胱癌亚洲诊治共识专家委员会委员、国科金终审专家、亚太前列腺癌学会(APPS)执行委员。
  主持国家级、省部级科研基金30余项。发表论文366篇(SCI 158篇)。主编主译专著8本,发明专利5项。以第一完成人获上海市科技进步一等奖、教育部科技成果一等奖、上海市医学科技奖一等奖、中华医学奖二等奖,2012年获国家科技进步一等奖(第三完成人)。获国家卫计委有突出贡献中青年专家,吴阶平泌尿外科医学奖,上海市领军人才,上海市医学领军人才,上海市优秀学科带头人称号,享受国务院特殊政府津贴。


研究领域:

  擅长泌尿男性生殖系统肿瘤早期诊断、根治手术和综合治疗,尤其擅长前列腺癌、膀胱癌和肾癌的根治性手术。


研究团队:

  泌尿外科现有医师16人,其中正高2人、副高5人、主治5人、住院4人、科研护士3人。在读研究生15人。


代表性论著:

  1. Zhang S#, Zhu Y, Ye D*. Phase II study of docetaxel, cisplatin, and fluorouracil in patients with distantly metastatic penile cancer as first-line chemotherapy. Oncotarget, 2015; 6(31):32212-19.
  2. Zhang GM#, Zhu Y, Ma XC, Qin XJ, Wan FN, Dai B, Sun LJ, Ye DW*. Pretreatment Neutrophil-to-Lymphocyte Ratio: A Predictor of Advanced Prostate Cancer and Biochemical Recurrence in Patients Receiving Radical Prostatectomy. Medicine (Baltimore), 2015 October; 94(41): e1473.
  3. Wan F#, Qin X, Zhang G, Lu X, Zhu Y, Zhang H, Dai B, Shi G, Ye D*. Oxidized low-density lipoprotein is associated with advanced-stage prostate cancer. Tumour Biol, 2015 May; 36(5):3573-82.
  4. Qu Y#, Dai B, Ye D*, Kong Y, Chang K, Jia Z, Yang X, Zhang H, Zhu Y, Shi G.Constitutively Active AR-V7 Plays an Essential Role in the Development and Progression of Castration-Resistant Prostate Cancer. Sci Rep, 2015 Jan 7; 5:7654.
  5. Qu Y#, Chen H, Gu W, Gu C, Zhang H, Xu J, Zhu Y, Ye D*. Age-Dependent Association between Sex and Renal Cell Carcinoma Mortality: a Population-Based Analysis. Sci Rep, 2015 Mar 17; 5:9160.
  6. Zhu YP#, Ye DW*. Re: A report from #BlueJC: Can chewing gum prevent postoperative ileus? BJOG, 2015 Mar; 122(4):596.
  7. Zhu YP#, Dai B, Zhang HL, Shi GH, Ye DW*. Impact of preoperative 5α-reductase inhibitors on perioperative blood loss in patients with benign prostatic hyperplasia: a meta-analysis of randomized controlled trials. BMC Urol, 2015 Jun 2; 15:47.
  8. Yi-Ping Zhu#, Fang-Ning Wan, Yi-Jun Shen, Hong-Kai Wang, Gui-Ming Zhang, Ding-Wei Ye*. Reactive stroma component COL6A1 is upregulated in castration-resistant prostate cancer and promotes tumor growth. Oncotarget, 2015 June 10; 6(16): 14488–14496.
  9. Lin GW#, Jia HX, Dai B, Zhang HL, Zhu Y, Shi GH, Ma CG,Ye DW*. Development of a preliminary nomogram to predict progression of bone scan for castration-resistant prostate cancer. Onco Targets Ther, 2015 Apr 7; 8:713-9.
  10. Zhang GM#, Wan FN, Qin XJ, Cao DL, Zhang HL, Zhu Y, Dai B, Shi GH, Ye DW*. Prognostic significance of the TREK-1 K2P potassium channels in prostate cancer. Oncotarget, 2015; 21(6):18460-8.
  11. Li Q#, Gu C, Zhu Y, Wang M, Yang Y, Wang J, Jin L, Zhu ML, Shi TY, He J, Ye D*, Wei Q. Two novel PRKCI polymorphisms and prostate cancer risk in an Eastern Chinese Han population. Mol Carcinog, 2015 Aug; 54(8):632-41.
  12. Gu C#, Qu Y, Zhang G, Sun L, Zhu Y, Ye D*. A single nucleotide polymorphism in ADIPOQ predicts biochemical recurrence after radical prostatectomy in localized prostate cancer. Oncotarget, 2015; 6(31):32205-11.
  13. Cao DL#, Dai B, Zhang HL, Shen YJ, Zhu Y, Zhu YP, Shi GH, Ma CG, Xiao WJ, Qin XJ, Lin GW, Ye DW*. Association of glutathione S-transferase T1 and M1 polymorphisms with prostate cancer susceptibility in populations of asian descent: a meta-analysis. Oncotarget, 2015; 6(34): 35843-35850.
  14. Wan FN#, Wang HK, Shen YJ, Zhang HL, Shi GH, Zhu Y, Dai B, Ye DW*. Upregulation of COL6A1 is predictive of poor prognosis in clear cell renal cell carcinoma patients. Oncotarget, 2015; 6(29):27378-87.
  15. Gu WJ#, Zhu Y, Wang HK, Zhang HL, Shi GH, Liu XH, Ye DW*. Prognostic value of components of body composition in patients treated with targeted therapy for advanced renal cell carcinoma: a retrospective case series. PLoS One, 2015 Feb 10; 10(2):e0118022.
  16. Zhu Y#, Gu WJ, Wang HK, Gu CY, Ye DW*. Surgical treatment of primary disease for penile squamous cell carcinoma: A Surveillance, Epidemiology, and End Results database analysis. OncolLett, 2015; 10(1):85-92.
  17. Zhu Y#, Yang XQ, Han CT, Dai B, Zhang HL, Shi GH, Wang CF, Ye DW*. Pathological Features of Localized Prostate Cancer in China: A Contemporary Analysis of Radical Prostatectomy Specimens. PLoS One, 2015 Mar 23; 10(3):e0121076.
  18. Zhang GM#, Zhu Y, Dong DH, Han CT, Gu CY, Gu WJ,Qin XJ, Sun LJ, Ye DW*. The association between metabolic syndrome and advanced prostate cancer in Chinese patients receiving radical prostatectomy. Asian J Androl, 2015 Sep-Oct; 17(5): 839–844.
  19. Zhang GM#, Gu CY, Zhu Y, Luo L, Dong DH, Wan FN, Zhang HL, Shi GH, Sun LJ, Ye DW*. ADIPOQ polymorphism rs182052 is associated with clear cell renal cell carcinoma. Cancer Sci, 2015 June; 106(6): 687–691.
  20. Dai B#, Kong YY, Chang K, Qu YY, Zhang SL, Zhang HL, Ye DW*. Primary invasive carcinoma associated with penoscrotalextramammary Paget's disease: A clinicopathologic analysis of 56 cases. BJU international, 2015; 115(1):153-160.
  21. Bian XJ#, ShenYJ, Zhang GM, GuCY, Cai Y, Wang CF, ZhuYP, Zhu Y, Zhang HL, Dai B, Ye DW*. Expression of Dicer and Its Related MiRNAs in the Progression of Prostate Cancer. PLoS One, 2015; 10(3): e0120159.
  22. Zhang GM#, Zhu Y, Gan HL, Wang HK, Shi GH, Zhang HL, Dai B, Wang CF, Ye DW*. Use of RENAL Nephrometry Scores for Predicting Tumor Upgrading Between Core Biopsies and Surgical Specimens: A Prospective Ex Vivo Study. Medicine (Baltimore), 2015 February; 94(8): e581.
  23. Zhang GM#, Qin XJ, Zhang HL, Xiao WJ, Zhu Y, Gu CY, Dai B, Shi GH, Ye DW*. Serum Lipid Profiles Are Novel Biomarkers Predicting Advanced Prostate Cancer in Patients Receiving Radical Prostatectomy. Asian J Androl, 2015 Mar-Apr; 17(2):239-44.
  24. Zhang GM#, Bao CY, Wan FN, Cao DL, Qin XJ, Zhang HL, Zhu Y , Dai B, Shi GH, Ye DW*. MicroRNA-302a Suppresses Tumor Cell Proliferation by Inhibiting AKT in Prostate Cancer. PLoS One, 2015; 10(4): e0124410.
  25. Zhu Y#, Wang HK, Qu YY, Ye DW*. Prostate cancer in East Asia: evolving trend over the last decade. Asian J Androl, 2015 Jan-Feb; 17(1): 48–57.
  26. Zhu Y#, Han CT, Zhang GM, Liu F, Ding Q, Xu JF, Adriana C. Vidal, Stephen J. Freedland, Chi-Fai Ng, Ding-Wei Ye*. Development and external validation of a prostate health index-based nomogram for predicting prostate cancer. Sci Rep, 2015; 5: 15341.
  27. Zhu YP#, Wang WJ, Zhang SL, Dai B, Ye DW*. Effects of gum chewing on postoperative ileus after cesarean section: A meta-analysis of randomised controlled trials. BJOG, 2014 Jun; 121(7):787-92.
  28. Zhu Y#, Ye DW*. Prostate cancer: Alkaline phosphatase velocity in nonmetastatic CRPC. Nat Rev Urol, 2014 Dec; 11(12):666-7.
  29. Na R#, Ye D#, Liu F, Chen H, Qi J, Wu Y, Zhang G, Wang M, Wang W, Sun J, Yu G, Zhu Y, Ren S, Zheng SL, Jiang H, Sun Y*, Ding Q*, Xu J*. Performance of serum prostate-specific antigen isoform [-2]proPSA (p2PSA) and the prostate health index (PHI) in a Chinese hospital-based biopsy population. Prostate, 2014 Nov; 74(15):1569-75.
  30. Wang JY#, Zhu Y# , Tang SX, Zhang HL, Qin XJ, Zhang SL, Dai B, Ye DW*. Prognostic significance of the degree of extranodal extension in patients with penile carcinoma. Asian J Androl, 2014; 16(3):437-41.
  31. Zhu YP#, Bian XJ, Ye DW*, et al. Long noncoding RNA expression signatures of bladder cancer revealed by microarray. OncolLett, 2014; 7(1):1197-1201.
  32. Ye L#, Yao XD#, Wan FN# , Qu YY, ShenXX, Yu LZ, Li S, Wang N, Liu XJ, Dai B, Ye DW*. MS4A8B Promotes Cell Proliferation in Prostate Cancer. Prostate, 2014 Jun; 74(9):911-22.
  33. Wang HK# , Song XS#, Cheng Y, Qu YY, Zhang SL, Dai B, Zhang HL, Shen YJ, Zhu YP, Shi GH, Qin XJ, Ma CG, Lin GW, Xiao WJ, Zhu Y*, Ye DW*. Visceral fat accumulation is associated with different pathological subtypes of renal cellcarcinoma (RCC): a multicentre study in China. BJU Int, 2014 Oct; 114(4):496-502.
  34. Cao DL#, Gu CY# ,Zhu Y, Dai B, Zhang HL, Shi GH, Shen YJ, Zhu YP,Ma CG, Xiao WJ, Qin XJ, Lin GW, Ye DW*. Polymorphisms at long non-coding RNAs and prostate cancer risk in an eastern Chinese population. Prostate Cancer and Prostatic Diseases, 2014 Dec; 17:315-319.
  35. Zhang GM#, Zhu Y#, Luo L, Zhang HL, Gu CY, Sun LJ, Ye DW*. Prevalence of dyslipidemia in patients with renal cell carcinoma: A case-control study in China. BJU Int, 2014 May; 113(5b):E75-81.
  36. Gu CY, Li QX, Zhu Y, Wang MY, Shi TY, Yang YY, Wang JC, Jin L, Wei QY, Ye DW*. Genetic variations of the ADIPOQ gene and risk of prostate cancer in Chinese Han men. Asian Journal of Andrology, 2014 Nov-Dec; 16(6):878-83. 
  37. Shen YJ, Kong ZL, Wan FN, Wang HK, Bian XJ, Gan HL, Wang CF, Ye DW*. Downregulation of DAB2IP results in cell proliferation and invasion and contributes to unfavorable outcomes in bladder cancer. Cancer Science, 2014 Jun; 105(6):704-12.
  38. Wang P#, Ye D#, Guo J, Liu F, Jiang H, Gong J, Gu C, Shao Q, Sun J, Zheng SL, Yu H, Lin X, Xia G, Fang Z, Zhu Y, Ding Q*, Xu J*. Genetic score of multiple risk-associated single nucleotide polymorphisms is a marker for genetic susceptibility to bladder cancer. Genes Chromosomes Cancer, 2014 Jan; 53(1):98-105.
  39. Zhu YP#, Bian XJ, Yao XD, Zhang SL, Dai B, Shen YJ, Ye DW*. PA-MSHA inhibits proliferation and induces apoptosis via caspases dependent manner in the human bladder cancer cell lines. Oncology Letters, 2013; 5:1357-1362.
  40. Zhu YP#, Yao XD, Zhang SL, Dai B, Shen YJ, Wang CF, Ye DW*. Defining good candidates for extraperitoneal cystectomy: Results from random peritoneum biopsies of 136 cases. Urology, 2013 Apr; 81(4):820-5.
  41. Dai B#, Qu YY#, Kong YY, Yao XD, Zhang SL, Zhang HL, Yang WY, Ye DW*. Kinetics of testosterone recovery in clinically localized prostate cancer patients treated with radical prostatectomy and subsequent short-term adjuvant androgen deprivation therapy. Asian J Androl, 2013 Jul; 15(4):466-70.
  42. Zhang HL#, Qin XJ, Cao DL, Zhu Y, Yao XD, Zhang SL, Dai B, Ye DW*. An elevated serum miR-141 level in patients with bone-metastatic prostate cancer is correlated with more bone lesions. Asian J Androl, 2013 Mar; 15(2):231-5.
  43. Zhu Y#, Zhou XY, Yao XD, Zhang SL, Dai B, Zhang HL, Shen YJ, Ye DW*. Prognostic value of carbonic anhydrase IX expression in penile squamous cell carcinoma: a pilot study. UrolOncol, 2013 Jul; 31(5):706-11.
  44. Zhu Y*, Wang HK#, Zhang HL, Yao XD, Zhang SL, Dai B, Shen YJ, Liu XH, Zhou LP, Ye DW*. Visceral obesity and risk of high grade disease in clinical t1a renal cell carcinoma. J Urol, 2013 Feb; 189(2):447-53.
  45. Li Q#, Gu C#, Zhu Y#, Wang M, Yang Y, Wang J, Jin L, Zhu ML, Shi TY, He J, Zhou X, Wei Q, Ye DW*. Polymorphisms in the mTOR Gene and Risk of Sporadic Prostate Cancer in an Eastern Chinese Population. PLoS One, 2013 Aug 5; 8(8):e71968.
  46. Shi GH#, Chen Y, Yao XD, Zhang SL, Dai B, Feng LQ, Zhang HL, Shen YJ, Zhu Y, Zhu YP, Xiao WJ, Ma CG, Wen LG, Qin XJ, Yang LF, Ye DW*. Individualized renal mass biopsy strategy for Chinese patients with different subtypes and necrosis area. Urol Oncol, 2013 Aug; 31(6):920-3.
  47. Qu YY#, Dai B, Kong YY, Chang K, Yao XD, Zhang SL, Zhang HL, Yang WY, Ye DW*. Influence of obesity on localized prostate cancer patients treated with radical prostatectomy. Asian Journal of Andrology, 2013; 15,747–752.
  48. Bian XJ#, Zhu Y, Shen YJ, Wang JY, Ma CG, Zhang HL, Dai B, Zhang SL, Yao XD, Ye DW*. The effectiveness of the TAX 327 nomogram in predicting overall survival in Chinese patients with metastatic castration-resistant prostate cancer. Asian J Androl, 2013; 15(5): 679–684.
  49. Dai B#, Qu YY, Kong YY, Yao XD, Zhang SL, Wang CF, Zhang HL, Yang WY, Ye DW*. Low pretreatment serum total testosterone is associated with high incidence of Gleason score 8-10 disease in prostatectomy specimens: data from Chinese localized prostate cancer patients. BJU Int, 2012 Dec; 110(11):667-672.
 
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