副研究员
危平 副研究员
副研究员,博士
E-mail: weiping@fudan.edu.cn
 

  2005年毕业于复旦大学上海医学院获得临床学士学位,2011年毕业于复旦大学生物医学研究院获得生物化学与分子生物学博士学位,2008-2011年在美国德州大学M.D. Anderson癌症研究中心从事研究助理和博士后的工作。2011年8月任职于复旦大学附属肿瘤医院肿瘤研究所。获得上海市浦江人才计划,主持或参加多项国家自然科学基金青年项目和面上项目,参加国家重大专项、上海市科委基础研究重大项目。研究成果发表于Cancer Cell, Cancer Research, Clinical Cancer Research等国际核心杂志。


研究领域:

  恶性肿瘤侵袭转移的分子机制及转化性研究,主要研究方向如下:
  1.癌基因FoxM1在恶性肿瘤转移中的机制研究;
  2.恶性肿瘤早诊、预后和转移预警相关的分子标志物的筛选和发病机制研究;
  3.肺癌和结直肠癌预后相关的分子分型模型研究。


代表性论著:

  1. Wang YQ, Zhou XR,Xu MD, Weng WW, Zhang QY , Yang YS, Wei P*, Du X*. OTUB1-catalyzed deubiquitination of FOXM1 facilitates tumor progression and predicts a poor prognosis in ovarian cancer. Oncotarget, 2016, 9160. [Epub ahead of print].
  2. Wei P#, Zhang N#, Wang Y#, Li D, Wang L, Sun X, Shen C, Yang Y, Zhou X, Du X. FOXM1 Promotes Lung Adenocarcinoma Invasion and Metastasis by Upregulating SNAIL. International Journal of Biological Sciences, 2015; 11(2):186-98.
  3. Liu Z#, Wei P#, Yang Y#, Cui W, Cao B, Tan C, Yu B, Bi R, Xia K, Chen W, Wang Y, Zhang Y, Du X, Zhou X. BATF2 deficiency promotes progression in human colorectal cancer via activation of HGF/MET signaling: a potential rationale for combining MET inhibitors with IFNs. Clinical Cancer Research, 2015; 21(7):1752-63.
  4. Sun X#, Wei P#, Shen C, Yang Y, Wang Y, Li Y, Du X. Prognostic value of the
IASLC/ATS/ERS classification and IMP3
expression in lung adenocarcinoma of Chinese cases. American journal of Cancer Research, 2015; 5(7):2266-76.
  5. Gong AH#, Wei P#, Zhang S#, Yao J, Yuan Y, Zhou AD, Lang FF, Heimberger AB, Rao G, Huang S. FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells. Cancer Research, 2015; 75(11):2337-48.
  6. Wei P#, Zhang N#, Xu Y, Li X, Shi D, Wang Y, Li D, Cai S. TPX2 is a novel prognostic marker for the growth and metastasis of colon cancer. Journal of Translational Medicine, 2013 Dec 17; 11:313.
  7. Xia Z#, Wei P#, Zhang H, Ding Z, Yang L, Huang Z, Zhang N. AURKA governs self-renewal capacity in glioma-initiating cells via stabilization/activation of beta-catenin/Wnt signaling. Molecular Cancer Research, 2013; 11(9):1101-11
  8. Li D#, Wei P#, Peng Z, Huang C, Tang H, Jia Z, Cui J, Le X, Huang S, Xie K. The Critical Role of Dysregulated FOXM1 – PLAUR Signaling in Human Colon Cancer Progression and Metastasis. Clinical Cancer Research, 2013; 19(1):62-72.
  9. Wei P#, Zhang W#, Yang LS#, Zhang HS, Xu XE, Jiang YH, Huang FP, Shi Q. Serum GFAP autoantibody as an ELISA-detectable glioma marker. Tumor Biology, 2013; 34(4):2283-92.
  10. Zhang N#, Wei P#, Gong A, Chiu WT, Lee HT, Colman H, Huang H, Xue J, Liu M, Wang Y, Sawaya R, Xie K, Yung WK, Medema RH, He X, Huang S.FoxM1 promotes beta-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell, 2011; 20(4):427-42.
 
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