副研究员
陈志翱 副研究员
副研究员,博士
E-mail: chenzhiao@shca.org.cn
 

  2004年毕业于复旦大学上海医学院临床专业,获医学学士学位。2009年毕业于复旦大学上海医学院医学分子病毒学重点实验室,获医学博士学位。2009年-2013年在上海市肿瘤研究所癌基因及相关基因国家重点实验室工作,2013年至今在复旦大学附属肿瘤医院肿瘤研究所工作,2018年11月至2019年4月在美国德克萨斯州大学健康科学中心(休斯敦)(UTHealth)生物化学与分子生物学系作为访问学者进修近半年,主要学习通过生物信息学整合分析已有的肿瘤大规模测序数据。主持项目包括高校博士点专项科研基金项目一项,上海市自然科学基金青年基金一项,上海市自然科学基金面上项目一项,国家自然科学基金两项,并作为课题骨干参与国家科技重大专项两项及国家自然科学基金多项。近5年主要研究成果发表于Genome Research, Cell Death & Disease, Frontiers in Pharmacology, Carcinogenesis, Cancer Science, Gastroenterology, Hepatology,以及Oncogene等杂志。在学术任职方面,担任Theranostics,  Cancel Cell International, journal of cancer和Biomedicine & Pharmacotherapy等SCI期刊审稿专家。


研究领域:

  消化系统恶性肿瘤发生与转移的分子机制和临床转化,主要包括:
  1. 肿瘤表观遗传学修饰及转录重编程在肿瘤中的作用机制;
  2. 肿瘤样本大数据及其生物信息分析在肿瘤中的应用研究。


代表性论著:

  1. Ruan H#, Xiang Y#, Ko J#, Li S#, Jing Y, Zhu X, Ye Y, Zhang Z, Mills T, Feng J, Liu CJ, Jing J, Cao J, Zhou B, Wang L, Zhou Y, Lin C, Guo AY, Chen X, Diao L, Li W, Chen Z, He X, Mills GB, Blackburn MR, Han L*. Comprehensive characterization of circular RNAs in ~ 1000 human cancer cell lines. Genome Med, 2019 Aug 26; 11(1):55.
  2. Zheng Q#, Zhao J#, Yu H, Zong H, He X, Zhao Y, Li Y, Wang Y, Bao Y, Li Y, Chen B, Guo W, Wang Y, Chen Z, Zhao Y, Wang L*, He X*, Huang S*. Tumor-Specific Transcripts Are Frequently Expressed in Hepatocellular Carcinoma With Clinical Implication and Potential Function. Hepatology, 2019 Jun 7.
  3. Zhiao Chen#, Xinyuan Lu#, Deshui Jia, Ying Jing, Di Chen, Qifeng Wang, Fangyu Zhao, Jinjun Li, Ming Yao, Wenming Cong, Xianghuo He*. Hepatic SMARCA4 Predicts HCC Recurrence and Promotes Tumour Cell Proliferation by Regulating SMAD6 Expression. Cell Death & Disease, 2018 Jan 19; 9(2):59.
  4. Xin-Yuan Lu#, Di Chen#, Xiao-Yuan Gu#, Jie Ding, Ying-Jun Zhao, Qian Zhao, Ming Yao, Zhi-Ao Chen*, Xiang-Huo He* and Wen-Ming Cong*. Predicting value of ALCAM as a target gene of microRNA-483-5p in patients with early recurrence in hepatocellular carcinoma. Frontiers in Pharmacology, 2018 Jan 12; 8:973.
  5. Tangjian Li#, Shengli Li#, Di Chen, Bing Chen, Tao Yu, Fangyu Zhao, Qifeng Wang, Ming Yao, Shenglin Huang, Zhiao Chen*Xianghuo He*. Transcriptomic analyses of RNA-binding proteins reveal eIF3c promotes cell  proliferation in hepatocellular carcinoma. Cancer Sci, 2017 May; 108(5):877-885.
  6. Zhaoping Qiu#, Weijie Guo#, Qifeng Wang, Zhiao Chen, Shenglin Huang, Fangyu Zhao, Ming Yao, Yingjun Zhao*, Xianghuo He*. MicroRNA-124 Reduces Pentose Phosphate Pathway and Proliferation by Targeting PRPS1 and RPIA mRNAs in Human Colorectal Cancer Cells. Gastroenterology, 2015 Nov; 149(6):1587-1598.
  7. Weijie Guo#, Zhaoping Qiu#, Zhichao Wang, Qifeng Wang, Ning Tan, Taoyang Chen, Zhiao Chen, Shengling Huang, Jianren Gu, Jinjun Li, Ming Yao, Yingjun Zhao*, Xianghuo He*. MiR-199a-5p is negatively associated with the malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer. Hepatology, 2015 Oct; 62(4):1132-44.
  8. Zhiao Chen#, Zhichao Wang#, Weijie Guo, Zhenfeng Zhang, Fangyu Zhao, Yingjun Zhao, Deshui Jia, Jie Ding, Hui Wang, Ming Yao and Xianghuo He*. TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma. Oncogene, 2015; 34(30): 3946-56.
 
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