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本科毕业于第二军医大学临床医学专业，2009年获生物化学与分子生物专业博士学位，同年进入东方肝胆外科医院国际合作生物信号转导研究中心（现为国家肝癌科学中心）工作，期间国家公派赴美国哥伦比亚大学交流学习。承担和完成国家自然科学基金青年、面上和优秀青年科学基金项目多项，担任新药创制科技重大专项首席科学家。入选上海市青年科技启明星、上海市浦江人才、上海高校青年教师培养资助计划、海军军医大学领航人才等人才计划；获得第十届吴孟超医学青年基金奖；现任全军生物技术专业委员会委员，上海市医学装备协会实验医学专业委员会常务委员；任JOCR杂志副主编。主要研究方向为肝癌早诊、分子分型和发生发展的机制。发表SCI收录论文30余篇，总影响因子超过300，代表性论文发表在Cell、Hepatology、Cancer Research等国际权威期刊，论文他引共计700余次。参编学术专著5部。获国家发明专利授权4项，软件著作权2项。
研究领域：
1. 肝癌发生发展的机制
2. 肝癌分子标志物和分子分型研究
代表性论著：
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Qi Xuewei, Chen Shuzhen, He Huisi, Wen Wen*, Wang Hongyang*.The role and potential application of extracellular vesicles in liver cancer. Sci China Life Sci. 2021 Aug; 64(8):1281-1294.
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Cao Qiqi, Wu Shipo, Xiao Chuanle, Chen Shuzhen, Chi Xiangyang, Cui Xiuliang, Tang Hao, Su Wenru, Zheng Yingfeng, Zhong Jiayong, Li Zhaomin, Li Fang, Chen Haijia, Hou Lihua, Wang Hongyang*, Wen Wen*. Integrated single-cell analysis revealed immune dynamics during Ad5-nCoV immunization. Cell Discov. 2021 Aug 10; 7(1):64.
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Wen Wen#, Ding Jin#, Sun Wen, Fu Jing, Chen Yao, Wu Kun, Ning Beifang, Han Tao, Huang Lei, Chen Cheng, Xie Dong, Li Zhong, Feng Gensheng, Wu Mengchao, Xie Weifen, Wang Hongyang. Cyclin G1-mediated epithelial-mesenchymal transition via phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progression. Hepatology. 2012 Jun; 55(6):1787-98.
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Ren Xianwen#, Wen Wen#, Fan Xiaoying#, Hou Wenhong#, Su Bin#, Cai Pengfei#, Li Jiesheng#, Liu Yang#, Tang Fei#, Zhang Fan#, Yang Yu#, He Jiangping#, Ma Wenji#, He Jingjing#, Wang Pingping#, Cao Qiqi, Chen Fangjin, Chen Yuqing, Cheng Xuelian, Deng Guohong, Deng Xilong, Ding Wenyu, Feng Yingmei, Gan Rui, Guo Chuang, Guo Weiqiang, He Shuai, Jiang Chen, Liang Juanran, Li Yi-Min, Lin Jun, Ling Yun, Liu Haofei, Liu Jianwei, Liu Nianping, Liu Shu-Qiang, Luo Meng, Ma Qiang, Song Qibing, Sun Wujianan, Wang GaoXiang, Wang Feng, Wang Ying, Wen Xiaofeng, Wu Qian, Xu Gang, Xie Xiaowei, Xiong Xinxin, Xing Xudong, Xu Hao, Yin Chonghai, Yu Dongdong, Yu Kezhuo, Yuan Jin, Zhang Biao, Zhang Peipei, Zhang Tong, Zhao Jincun, Zhao Peidong, Zhou Jianfeng, Zhou Wei, Zhong Sujuan, Zhong Xiaosong, Zhang Shuye, Zhu Lin, Zhu Ping, Zou Bin, Zou Jiahua, Zuo Zengtao, Bai Fan, Huang Xi, Zhou Penghui, Jiang Qinghua, Huang Zhiwei, Bei Jin-Xin, Wei Lai, Bian Xiu-Wu, Liu Xindong, Cheng Tao, Li Xiangpan, Zhao Pingsen, Wang Fu-Sheng, Wang Hongyang, Su Bing, Zhang Zheng, Qu Kun, Wang Xiaoqun, Chen Jiekai, Jin Ronghua, Zhang Zemin. COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas. Cell. 2021 Apr 1; 184(7):1895-1913.
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Wen Wen#, Su Wenru#, Tang Hao#, Le Wenqing#, Zhang Xiaopeng#, Zheng Yingfeng#, Liu Xiuxing, Xie Lihui, Li Jianmin, Ye Jinguo, Dong Liwei, Cui Xiuliang, Miao Yushan, Wang Depeng, Dong Jiantao, Xiao Chuanle, Chen Wei, Wang Hongyang. Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing. Cell Discovery. 2020 May 4; 6:31.
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Wen Wen#, Ding Jin#, Sun Wen, Wu Kun, Ning Beifang, Gong Wenfeng, He Guoping, Huang Shanna, Ding Xinyu, Yin Peipei, Chen Lei, Liu Qiong, Xie Weifen, Wang Hongyang. Suppression of cyclin D1 by hypoxia-inducible factor-1 via direct mechanism inhibits the proliferation and 5-fluorouracil-induced apoptosis of A549 cells. Cancer Res. 2010 Mar 1;70(5):2010-9.
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Ke Shizhong, Chen Shuzhen, Dong Zihui, Hong Christopher S, Zhang Qi, Tang Liang, Yang Pinghua, Zhai Jian, Yan Hexin, Shen Feng, Zhuang Zhengping, Wen Wen*, Wang Hongyang*. Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations. Hepatology. 2017 Jan; 65(1):134-151.
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