专职PI

唐爽 青年研究员
青年研究员,博士生导师


E-mail: tangshuang@fudan.edu.cn

实验室网页:https://www.x-mol.com/groups/tang_shuang


 

  唐爽,复旦大学附属肿瘤医院青年研究员,博士研究生导师,国家海外高层次人才引进项目获得者(2019)。2009年毕业于上海交通大学医学院临床医学系,2015年获得上海交通大学医学院与美国国立卫生研究院NIH联合培养医学博士学位, 并于2018年在美国杜克大学医学院再获临床研究硕士学位。2015-2020年先后在美国NIH和哈佛大学医学院从事博士后研究工作,获得2017年美国NIH Women Scientist Advisors Award, 2018年被评选为Helen Fellow by The Helen Gurley Brown Presidential Initiative20209月至今,任职复旦大学附属肿瘤医院青年研究员,获国家海外高层次人才引进项目,国家自然科学基金资助。代表性学术成果发表在Molecular Cell20142018),EMBO Journal2017, Trends in Endocrinology & Metabolism (2019,2021), Cell Metabolism (2020)等国际一流学术期刊。


研究方向:代谢与核医学


  结合同位素标记技术以及细胞生物学,分子生物学,代谢组学和小鼠模型等多种方法,研究代谢和蛋白质修饰如何调节快速增殖细胞(干细胞和癌细胞)对微环境的适应性,并结合代谢分子成像技术开展肿瘤精准诊疗与监测的转化研究;


代表性论著:

  1. Tang S, Huang G*, Fan W, Chen Y, Ward JM, Xu X, Xu Q, Kang A, McBurney MW, Fargo DC, Hu G, Baumgart-Vogt E, Zhao Y, Li X*. SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation. Molecular Cell. 2014 Sep 18; 55(6):843-855.
  2. Crowley M, Diamantidis C, McDuffie J, Cameron CB, Stanifer JW, Mock CK, Wang X, Tang S, Nagi A, Kosinski AS, Williams JW*. Clinical Outcomes of Metformin Use in Populations with Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease: A Systematic Review. Annals of internal medicine. 2017 Feb 7; 166(3):191-200.
  3. Tang S, Fang Y, Huang G, Xu X, Padilla-Banks E, Fan W, Xu Q, Sanderson SM, Foley JF, Dowdy S, McBurney MW, Fargo DC, Williams CJ, Locasale JW, Guan Z, Li X*. Methionine is essential for SIRT1-regulated mESC maintenance and embryonic development. EMBO Journal. 2017 Nov 2; 36(21):3175-3193.
  4. Huang H#, Tang S#, Jing M#, Tang Z, Shimada M, Liu X, Qi S, Locasale J, Roeder R, Zhao Y*, and Li X*. p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis. Molecular Cell. 2018 May 17; 70:663-678.
  5. Fang Y#, Tang S#, Li X*. Sirtuins in Metabolic and Epigenetic Regulation of Stem Cells. Trends in Endocrinology & Metabolism. 2019 Mar; 30(3):177-188.
  6. Tang S,Li X*,Locasale J*. Dietary Methionine in T Cell Biology and Autoimmune Disease. Cell Metabolism. 2020 Feb 4;31(2):211-212.
  7. Fan W, Tang S, Fan X, Fang Y, Xu X, Li L, Xu J, Li J, Wang Z*, Li X*. SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B. Elife. 2021 May 27; 10:e67452.
  8. Liu Y#, Zhou Q#, Song S*Tang S*. Integrating metabolic reprogramming and metabolic imaging to predict breast cancer therapeutic responses. Trends in Endocrinology & Metabolism.  2021 Oct; 32(10):762-775.
 
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