闫明霞 研究员 研究员，博士 E-mail: mingxia_yan@126.com

      2000年毕业于佳木斯大学临床医学专业获得临床学士学位，2005年毕业于复旦大学动物学专业获得理学硕士学位，2011年毕业于上海交通大学肿瘤学专业获得肿瘤学博士学位。2005年7月-2018年5月就职于上海市肿瘤研究所，2018年6月起就职于复旦大学附属肿瘤医院，担任肿瘤研究所实验动物平台主管。目前任上海市实验动物学会理事，上海市实验动物学会资源与设施专业委员会副主任委员，担任《实验动物与比较医学》编委。工作以来主要从事肿瘤高转移动物模型筛选及建立、肿瘤转移相关分子机制等研究工作。以第一作者、通讯作者发表论文10余篇，参与发表论文20余篇；以第一责任人申请国家自然科学基金2项、上海市科委“创新行动计划”等课题8项，总经费约300万元，作为骨干参与国家“973”、国家十二五科技重大公关等课题研究；以第一发明人申请国家发明专利4项，参与申请5项，其中2项获得专利授权。参编专业书籍2本，获得上海医学科技奖三等奖1项。

研究领域：

　　肿瘤转移的分子机制研究及抗肿瘤转移的治疗研究：
　　1. 肿瘤转移动物模型的筛选及建立
　　2. 基于动物模型的抗肿瘤转移治疗研究
　　3. 肿瘤转移的分子机制研究

代表性论著：

1.  Li Jing^#, Cheng Dongdong^#, Zhu Miaoxin, Yu Huajian, Pan Zhen, Liu Lei, Geng Qin, Pan Hongyu, Yan Mingxia^*, Yao Ming^*.OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer. Theranostics, 2019; 9(1):179–195.

   metastasis of human non-small-cell lung cancer by downregulating the ERBB4/PIK3R3/mTOR/S6K2signaling pathway. Oncogene, 2015; 34:413-423.

2. Chu D^#, Li J^#, Lin H, Zhang X, Pan H, Liu L, Yu T, Yan M^*, Yao M^*.Quantitative proteomic analysis of the miR-148a-associated mechanisms of metastasis in non-small cell lung cancer.Oncol Lett., 2018; 15(6):9941–9952.

3. Hechun Lin^#, Xiao Zhang^#, Li Liao, Tao Yu, Jing Li, Hongyu Pan, Lei Liu, Hanwei Kong, Lei Sun, Mingxia Yan^*, Ming Yao^*. CPNE3 promotes migration and invasion in non-small cell lung cancer by interacting with RACK1 via FAK signaling activation. J Cancer., 2018; 9(22):4215–4222.

4. Dandan Chu^#, Jing Li^#, Hechun Lin, Xiao Zhang, Hongyu Pan, Lei Liu, Tao Yu, Mingxia Yan^*, Ming Yao^*. Quantitative proteomic analysis of the miR-148a-associated mechanisms of metastasis in non-small cell lung cancer.OncolLett., 2018; 15(6):9941–9952.

5. Yu T^#, Zhao Y^#, Hu Z, Li J, Chu D, Zhang J, Li Z, Chen B, Zhang X, Pan H, Li S, Lin H, Liu L, Yan M, He X^*, Yao M^*.MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway.Cancer Res., 2017; 77(21):5782-5794.

6. Wei Deng^#, Mingxia Yan^#, Tao Yu, Haiyan G, Hechun Lin, JingLi, Ying Liu, Qin Geng, Miaoxin Zhu, Lei Liu, Xianghuo He^*, Ming Yao^*. Quantitative proteomic analysis of the metastasis-inhibitory mechanism of miR-193a-3pin non-small cell lung cancer.Cell PhysiolBiochem., 2015; 35:1677-1688.

7. Cui YQ^#, Geng Q, Yu T, Zhang FL, Lin HC, Li J, Zhu MX, Liu L, Yao M^*, Yan MX^*. Establishment of a highly metastatic model with a newly isolated lung adenocarcinoma cell line.Int JOncol., 2015; 47(3):927-940.

8. Jing Li^#, Tao Yu^#, Jun Cao, Lei Liu, Ying Liu, Han-Wei Kong, Miao-Xin Zhu, He-Chun Lin, Dan-danChu, Ming Yao^*, Ming-Xia Yan^*.MicroRNA-148a Suppresses Invasion and Metastasis of Human Non-Small-Cell Lung Cancer. Cell PhysiolBiochem., 2015; 37:1847-1856.

9. Mingxia Yan^#, Hong Li, Miaoxin Zhu, Fangyu Zhao, Lixing Zhang, Taoyang Chen, Guoping Jiang, HaiyangXie, Ying Cui, Ming Yao, Jinjun Li^*.GProtein-Coupled Receptor 87 (GPR87) promotes the growth and metastasis of CD133⁺ cancer stem-like cells in hepatocellular carcinoma. PLoS ONE, 2013; 8(4): e61056.

10. Mingxia Yan^#, Hong Li, Fangyu Zhao, Lixing Zhang, Chao Ge, Ming Yao, Jinjun Li^*.Establishment of NOD/SCID mouse models of human hepatocellular carcinoma via subcutaneous transplantation of histologically intact tumor tissue. Chin J Cancer Res., 2013; 25(3): 289-298.

11.  Tao Yu^#, Jing Li, Mingxia Yan, Lei Liu, Hechun Lin, Fangyu Zhao, Lei Sun, Yu Zhang, Yongqi Cui, Fanglin Zhang, Jinjun Li, Xianghuo He, Ming Yao^*. MicroRNA-193a-3p and -5p suppress the