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蔡振宇 研究员
研究员
 

  组部第十三批“青年千人”计划入选者。2003年与2006年分别于湖南师范大学获理学学士与硕士学位,2010年于美国德州农工大学健康科学中心获生物医学专业博士学位。20112月至20172月在美国国立卫生研究院国立癌症研究所做访问学者。20179月起任肿瘤研究所王红阳院士工作站PI。主要从事程序性细胞死亡的分子机制及其相关肿瘤炎症疾病的研究。获中组部“青年千人”计划、国家自然科学基金面上项目和上海市科委国际合作等可研项目资助。近五年来,研究成果以通讯作者或第一作者发表在Nat Cell Biol, Cell ResProc Natl Acad Sci U S A, Cancer Res, Br J Pharmacol J Med Chem JBC等杂志。其中两篇论文入选ESI1%高被引论文。申报国内专利2项 。


研究领域:

  1. 程序性细胞死亡及其所诱发的炎症反应与肿瘤发生发展的关系;
  2. 抗坏死小分子药物筛选、鉴定与临床应用;
  3. 程序性细胞死亡的分子机制。


代表性论著:

  1. Qin X, Ma D, Tan Y*, Wang H*, Cai Z*. The role of necroptosis in cancer: a double-edged sword? Biochim Biophys Acta Rev Cancer,  2019; 1871:259-266.
  2. Chen X#, Zhuang C#,*, Ren Y#, Zhang H, Qin X, Hu L, Fu J, Miao Z, Chai Y, Liu Z, Cai Z*, Wang H* , Identification of TAK-632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3. Br J Pharmacol, 2019; 176(12):2095-2108.
  3. Zhang H#, Xu L#, Qin X#, Chen X, Cong H, Hu L, Miao Z, Zhang W*, Cai Z*, Zhuang C*. TAK-632 Analogues as Novel Necroptosis Inhibitors Selectively Targeting RIPK3: Synthesis, Structure-Activity Relationships and In Vivo Efficacy.  J Med Chem, 2019; 25; 62(14):6665-6681.
  4. Cai Z, Zhang A, Choksi S, Li W, Li T, Zhang X, and Liu Z. Activation of cell surface proteases promotes necroptosis, inflammation and cell migration. Cell Research, 2016; 26(8):886-900.
  5. Cai Z, Jitkaew S, Zhao J, Chiang H, Choksi S, Liu J, Ward E, Wu L, Liu Z. Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis. Nat Cell Biol, 2014; 16(1):55-65.
  6. Zhao J#, Jitkaew S#, Cai Z#, Choksi S, Li Q, Luo J, Liu ZG. Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. Proc Natl Acad Sci U S A, 2012; 109(14):5322-7.
  7. Cai Z, Sancheza A, Shi Z, Zhang T, Liu M, Zhang D. Activation of Toll-Like receptor 5 on breast cancer cells by flagellin suppresses cell proliferation and tumor Growth. Cancer Res. 2011; 71(7):2466-75.
  8. Cai Z, Shi Z, Sanchez A, Zhang T, Liu M, Yang J, Wang F, Zhang D. Transcriptional regulation of TLR11 gene expression in epithelial cells. J Biol Chem. 2009; 284(48):33088-96.
 
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