专职PI
何祥火 研究员
研究员,博士生导师
E-mail: xhhe@fudan.edu.cn
 

  1995年与1998年于华东师范大学获本科及理学硕士学位;2003年于复旦大学获理学博士学位。2003年至2006年于美国UT M.D.安德森癌症中心分子与细胞肿瘤学系从事博士后研究。2006年至2013年任职于上海市肿瘤研究所癌基因及相关基因国家重点实验室,研究员,PI。2014年至今任职于复旦大学生物医学研究院及复旦大学附属肿瘤医院/肿瘤研究所,研究员,博士生导师。
  2011年国家杰出青年科学基金获得者。曾入选教育部新世纪优秀人才、上海市优秀学术带头人、上海市医学领军人才、上海市浦江人才、上海市教委曙光学者、上海卫生系统优秀学科带头人;曾获吴孟超医学基金奖一等奖、银蛇奖、明治生命科学奖;曾获教育部自然科学奖二等奖及上海医学科技奖二等奖。
  主要从事消化系恶性肿瘤发生与转移的分子机理研究,已发表SCI论文70余篇,包括Nature Cell Biology, Gastroenterology, Hepatology, Cell Research, Nucleic Acids Research, Cancer Research, Oncogene, Clinical Cancer Research, Science Signaling等国际学术期刊;论文被引2600余次。


研究领域:

  主要从事消化系恶性肿瘤发生与转移的分子机理研究,研究方向包括:
  1.非编码RNA调控网络及其分子机制;
  2.癌基因鉴定、功能与细胞信号转导;
  3.肿瘤基因组学与生物信息学。


研究团队:



代表性论著:

  1. Zhaoping Qiu#, Weijie Guo#, Qifeng Wang#, Zhiao Chen, Shenglin Huang, Fangyu Zhao, Ming Yao, Yingjun Zhao*, Xianghuo He*. MicroRNA-124 Reduces Pentose Phosphate Pathway and Proliferation by Targeting PRPS1 and RPIA mRNAs in Human Colorectal Cancer Cells. Gastroenterology, 2015 Nov; 149(6):1587-1598.e11.
  2. Weijie Guo#, Zhaoping Qiu#, Zhichao Wang#, Qifeng Wang,Ning Tan, Taoyang Chen, Zhiao Chen, Shenglin Huang, Jianren Gu, Jinjun Li, Ming Yao, Yingjun Zhao*, Xianghuo He*. MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer. Hepatology, 2015 Oct; 62(4):1132-44.
  3. Yan Li#, Qiupeng Zheng#, Chunyang Ba, Shuyi Li, Weijie Guo, Jiang Zhao, Di Chen, Jianren Gu, Xianghuo He*, Shenglin Huang*. Circular RNA is enriched and stable in the exosome: a promising biomarker for cancer diagnosis. Cell Research, 2015 Aug; 25(8):981-4.
  4. Chunyang Bao#, Yan Li#, Lin Huan, Yuannv Zhang, Fangyu Zhao, Qifeng Wang, Linhui Liang, Jie Ding, Li Liu, Taoyang Chen, Jinjun Li, Ming Yao, Shenglin Huang*, Xianghuo He*. NF-κB signaling relieves negative regulation by miR-194 in hepatocellular carcinoma by suppressing the transcription factor HNF-1α. Science Signaling, 2015 Jul 28; 8(387):ra75.
  5. Zhiao Chen#, Zhichao Wang#, Weijie Guo, Zhenfeng Zhang, Fangyu Zhao, Yingjun Zhao, Deshui Jia, Jie Ding, Hui Wang, Ming Yao, Xianghuo He*. TRIM35 Interacts with pyruvate kinase isoform M2 to Suppress the Warburg Effect and Tumorigenicity in Hepatocellular Carcinoma. Oncogene, 2015 Jul 23; 34(30):3946-56.
  6. Zhiao Chen#, Xinyuan Lu#, Zhi-Chao Wang, Guangzhi Jin, Qifeng Wang, Di Chen, Taoyang Chen, Jinjun Li, Jia Fan, Wenming Cong*, Qiang Gao*, and Xianghuo He*. Co-expression of PKM2 and TRIM35 Predicts Survival and Recurrence in Hepatocellular Carcinoma. Oncotarget, 2015 Feb 10; 6(4):2538-48.
  7. Yan Li#, Dan Xu#, Chunyang Bao#, Yuannv Zhang, Di Chen, Fangyu Zhao, Jie Ding, Linhui Liang, Qifeng Wang, Li Liu, Jinjun Li, Ming Yao, Shenglin Huang*, Xianghuo He*. MicroRNA-135b, a HSF1 Target, Promotes Tumor Invasion and Metastasis by Regulating RECK and EVI5 in Hepatocellular Carcinoma. Oncotarget, 2015 Feb 10; 6(4):2421-33.
  8. Deshui Jia#, Rui Dong#, Ying Jing#, Dan Xu#, Qifeng Wang, Lei Chen, Qigen Li, Yuping Huang, Yuannv Zhang, Zhenfeng Zhang, Li Liu, Shan Zheng, Qiang Xia, Hongyang Wang*, Kuiran Dong*, Xianghuo He*. Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex. Hepatology, 2014 Nov; 60(5): 1686–1696.
  9. Qiang Gao#, Ying-Jun Zhao#, Xiao-Ying Wang#, Wei-Jie Guo, Song Gao, Lin Wei, Jie-Yi Shi, Guo-Ming Shi, Zhi-Chao Wang, Yuan-Nv Zhang, Ying-Hong Shi, Jie Ding, Zhen-Bin Ding, Ai-Wu Ke, Zhi Dai, Fei-Zhen Wu, Hui Wang, Zhao-Ping Qiu, Zhi-Ao Chen, Zhen-Feng Zhang, Shuang-Jian Qiu, Jian Zhou*, Xiang-Huo He*, Jia Fan*. Activating Mutations in PTPN3 Promote Cholangiocarcinoma Cell Proliferation and Migration and are Associated with Tumor Recurrence in Patients. Gastroenterology, 2014 May; 146(5):1397-1407.
  10. Qifeng Wang#, Zhaohui Huang#, Weijie Guo#, Shujuan Ni, Xiuying Xiao, Lisha Wang, Dan Huang, Cong Tan, Qinghua Xu, Ruopeng Zha, Jiwei Zhang,Weiqi Sheng, Xianghuo He*, Xiang Du*. MicroRNA-202-3p Inhibits Cell Proliferation by Targeting ADP-Ribosylation Factor-Like 5A in Human Colorectal Carcinoma. Clinical Cancer Research, 2014 Mar; 20(5):1146-1157.
  11. Deshui Jia#, Ying Jing, Zhenfeng Zhang, Li Liu, Jie Ding, Fangyu Zhao, Chao Ge, Qifeng Wang, Taoyang Chen, Ming Yao, Jinjun Li, Jianren Gu, Xianghuo He*. Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma. Cell Research, 2014 Feb; 24(2): 204-17.
  12. Ying Jing#, Deshui Jia#, Chun-Ming Wong, Irene Oi-Lin Ng, Zhenfeng Zhang, Li Liu, Qifeng Wang, Fangyu Zhao, Jinjun Li, Ming Yao, Xingzhong Wu*, Xianghuo He*. SERPINA5 inhibits tumor cell migration by modulating the fibronectin-integrin β1 signaling pathway in hepatocellular carcinoma. Molecular Oncology, 2014 Feb; 8(2): 366-377.
  13. Jie Ding#, Shenglin Huang#, Ying Wang, Qi Tian, Ruopeng Zha, Haibing Shi, Qifeng Wang, Chao Ge, Taoyang Chen, Yingjun Zhao, Linhui Liang, Jinjun Li, Xianghuo He*. Genome-wide screening revealed that miR-195 targets the TNF-α/NF-κB pathway by downregulating IKKα and TAB3 in hepatocellular carcinoma. Hepatology, 2013 Aug; 58(2):654-66.
  14. Guihao Ke#, Linhui Liang, Jin-Ming Yang, Xiao Huang, Duo Han, Shenglin Huang, Yingjun Zhao, Ruopeng Zha, Xianghuo He*, Xiaohua Wu*. MiR-181a Confers Resistance of Cervical Cancer to Radiation Therapy through Targeting the Pro-apoptotic PRKCD Gene. Oncogene, 2013 Jun; 32: 3019-3027.
  15. Biqiang Zheng#, Linhui Liang#, Shenglin Huang, Ruopeng Zha, Li Liu, Deshui Jia, Qi Tian, Qifeng Wang, Chunmong Wang, Ziwen Long, Ye Zhou, Xi Cao, Chunyan Du, Yingqiang Shi*, Xianghuo He*. MicroRNA-409 Suppresses Tumor Cell Invasion and Metastasis by Directly Targeting Radixin in Gastric Cancers. Oncogene, 2012 Oct 18; 31(42):4509-16.
  16. Qiang Gao#, Ying-Jun Zhao#, Xiao-Ying Wang#, Shuang-Jian Qiu, Ying-Hong Shi, Jian Sun, Yong Yi, Jie-Yi Shi, Guo-Ming Shi, Zhen-Bin Ding, Yong-Sheng Xiao, Zhong-Hua Zhao, Jian Zhou*, Xiang-Huo He*, Jia Fan*. CXCR6 upregulation contributes to a pro-inflammatory tumor microenvironment that drives metastasis and poor patient outcomes in hepatocellular carcinoma. Cancer Research, 2012 Jul 15; 72(14):3546-56.
  17. Biqiang Zheng#, Linhui Liang, Chunmong Wang, Shenglin Huang, Xi Cao, Ruopeng Zha, Li Liu, Deshui Jia, Qi Tian, Jianghong Wu, Yanwei Ye, Qifeng Wang, Ziwen Long, Ye Zhou, Chunyan Du, Xianghuo He*, Yingqiang Shi*. MicroRNA-148a Suppresses Tumor Cell Invasion and Metastasis by Downregulating ROCK1 in Gastric Cancer. Clinical Cancer Research, 2011 Dec 15; 17(24):7574-83.
  18. Qiao Ying#, Linhui Liang#, Weijie Guo, Ruopeng Zha, Qi Tian, Shenglin Huang, Jian Yao, Jie Ding, Meiyan Bao, Chao Ge, Ming Yao, Jinjun Li, Xianghuo He*. Hypoxia-inducible miR-210 augments the metastatic potential of tumor cells by targeting VMP1 in hepatocellular carcinoma. Hepatology, 2011 Dec; 54 (6): 2064-2075.
  19. Jun Lin#, Shenglin Huang#, Shunquan Wu, Jie Ding, Yingjun Zhao, Linhui Liang, Qi Tian, Ruopeng Zha, Rong Zhan*, Xianghuo He*. MicroRNA-423 Promotes Cell Growth and Regulates G1/S Transition by targeting p21Cip1/Waf1 in Hepatocellular Carcinoma. Carcinogenesis, 2011 Nov; 32 (41): 1641-1647.
  20. Deshui Jia#, Lin Wei, Weijie Guo, Ruopeng Zha, Meiyan Bao, Zhiao Chen, Yingjun Zhao, Chao Ge, Fangyu Zhao, Taoyang Chen, Ming Yao, Jinjun Li, Hongyang Wang, Jianren Gu, Xianghuo He*. Genome-Wide Copy Number Analyses Identified Novel Cancer Genes in Hepatocellular Carcinoma. Hepatology, 2011 Oct; 54(4):1227-36.
  21. Zhaohui Huang#, Shenglin Huang, Qifeng Wang, Linhui Liang, Shujuan Ni, Lisha Wang,Weiqi Sheng, Xianghuo He*, Xiang Du*. MicroRNA-95 Promotes Cell Proliferation and Targets Sorting Nexin 1 in Human Colorectal Carcinoma. Cancer Research, 2011 Apr 1; 71(7); 2582–2589.
  22. Yingjun Zhao#, Xiaoying Wang#, Tao Wang, Xin Hu, Xin Hui, Mingxia Yan, Qiang Gao, Taoyang Chen, Jinjun Li, Ming Yao, Dafang Wan, Jianren Gu*, Jia Fan*, Xianghuo He*. Acetylcholinesterase, a Key Prognostic Predictor for Hepatocellular Carcinoma, Suppresses Cell Growth and Induces Chemosensitization. Hepatology, 2011 Feb; 53 (2):493-503.
  23. Linhui Liang#, Chun-Ming Wong, Qiao Ying, Dorothy Ngo-Yin Fan, Shenglin Huang, Jie Ding, Jian Yao, Mingxia Yan, Jinjun Li, Ming Yao, Irene Oi-Lin Ng, Xianghuo He*. MicroRNA-125b Suppressed Human Liver Cancer Cell Proliferation and Metastasis by Directly Targeting Oncogene LIN28B2. Hepatology, 2010 Nov; 52 (5): 1731-1740.
  24. Shenglin Huang#, Shunquan Wu, Jie Ding, Jun Lin, Lin Wei, Jianren Gu, Xianghuo He*. MicroRNA-181a Modulates Gene Expression of Zinc Finger Family Members by Directly Targeting Their Coding Regions. Nucleic Acids Research, 2010 Nov; 38 (20):7211-7218.
  25. Jie Ding#, Shenglin Huang#, Shunquan Wu, Yingjun Zhao, Linhui Liang, Mingxia Yan, Chao Ge, Jian Yao, Taoyang Chen, Dafang Wan, Hongyang Wang, Jianren Gu, Ming Yao, Jinjun Li, Hong Tu, Xianghuo He*. Gain of miR-151 on Chromosome 8q24.3 Facilitates Tumor Cell Migration and Spreading through Downregulating RhoGDIA. Nature Cell Biology, 2010 Apr; 12 (4): 390-399.
  26. Shunquan Wu#, Shenglin Huang#, Jie Ding, Linhui Liang, Yingjun Zhao, Te Liu, Rong Zhan*, Xianghuo He*. Multiple MicroRNAs Modulate p21Cip1/Waf1 Expression by Directly Targeting Its 3′ Untranslated Region. Oncogene, 2010 Apr; 29 (15): 2302-2308.
  27. Jian Yao#, Linhui Liang, Shenglin Huang, Jie Ding, Ning Tan, Yingjun Zhao, Mingxia Yan, Chao Ge, Zhenfeng Zhang, Taoyang Chen, Dafang Wan, Ming Yao, Jinjun Li, Jianren Gu, Xianghuo He*. MicroRNA-30d Promotes Tumor Invasion and Metastasis by Targeting Galphai2 in Hepatocellular Carcinoma. Hepatology, 2010 Mar; 51 (3): 846-856.

  28. Invited Review:
  29. Shenglin Huang#, Xianghuo He*. The Role of MicroRNAs in Liver Cancer Progression. British Journal of Cancer, 2011; 104 (2): 235-240.
  30. Lin-Hui Liang#, Xiang-Huo He*. Macro-Management of MicroRNAs in the Cell Cycle Progression of Tumor Cells and Its Implications in Anti-Cancer Therapy. Acta Pharmacologica Sinica, 2011; 32 (11):1311-1320.
  31. Shenglin Huang#, Xianghuo He*. MicroRNAs: Tiny RNA Molecules, Huge Driving Forces to Move the Cell. Protein & Cell, 2010; 1 (10): 916-926.
 
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