专职PI
何祥火 研究员

复旦大学肿瘤研究所副所长

研究员,博士生导师,复旦大学特聘教授

E-mail: xhhe@fudan.edu.cn
 

  1995年与1998年于华东师范大学获本科及理学硕士学位;2003年于复旦大学获理学博士学位。2003年至2006年于美国UT M.D.安德森癌症中心从事博士后研究。2006年至2013年任职于上海市肿瘤研究所癌基因及相关基因国家重点实验室,研究员,PI2014年至今任职于复旦大学生物医学研究院及复旦大学附属肿瘤医院/肿瘤研究所,研究员,博士生导师,复旦大学特聘教授。
  2011年国家杰出青年科学基金获得者、2017年入选第三批国家“万人计划”领军人才。曾入选科技部中青年创新领军人才、教育部新世纪优秀人才、上海市优秀学术带头人、上海市医学领军人才、上海市浦江人才、上海市教委曙光学者、上海卫生系统优秀学科带头人;曾获吴孟超医学基金奖一等奖、银蛇奖、明治生命科学奖;曾获教育部自然科学奖二等奖及上海医学科技奖二等奖。
  研究领域为肿瘤分子生物学,主要从事消化系恶性肿瘤发生与转移的分子机理研究,已发表论文100余篇,包括Nature Cell Biology, Gastroenterology, Hepatology, Cell Research, Nature Communications, Nucleic Acids Research, Cancer Research, Clinical Cancer Research, Cell Reports, Oncogene, Science Signaling 等国际学术期刊;论文被引6650余次, H-index为42(至2019-12)。


研究领域:

  肿瘤分子生物学,研究方向包括:
  1.非编码RNA功能及分子机制;
  2.RNA可变剪接异常及调控机制;
  3.转录重编程及表观调控机制。


研究团队:



代表性论著*为通讯作者)

  1. Hu Z, Dong L, Li S, Li Z, Qiao Y, li Y, Ding J, Chen z, Wu Y, Wang  Z, Huang S, Gao Q*, Zhao Y*, He X*. Splicing Regulator p54nrb/NONO Enhances Carcinogenesis Through Oncogenic Isoform Switch of BIN1 in Hepatocellular Carcinoma. Hepatology, 2019 Dec 9. doi:10.1002/hep.31062.
  2. Zheng Q, Zhao J, Yu H, Zong H, He X, Zhao Y, Li Y, Wang Y, Bao Y, Li Y, Chen B, Guo W, Wang Y, Chen Z, Zhao Y, Wang L*, He X*, Huang S*. Tumor-Specific Transcripts Are Frequently Expressed in Hepatocellular Carcinoma With Clinical Implication and Potential Function. Hepatology, 2019 Jun 7. doi: 10.1002/hep.30805.
  3. Li Y, Zhao J, Yu S, Wang Z, He X, Su Y, Guo T, Sheng H, Chen J, Zheng Q, Li Y, Guo W, Cai X, Shi G, Wu J, Wang L, Wang P, He X*, Huang S*. Extracellular Vesicles Long RNA Sequencing Reveals Abundant mRNA, circRNA, and lncRNA in Human Blood as Potential Biomarkers for Cancer Diagnosis. Clin Chem, 2019 Jun; 65(6): 798-808.
  4. Li S, Hu Z, Zhao Y, Huang S, He X*. Transcriptome-Wide Analysis Reveals the Landscape of Aberrant Alternative Splicing Events in Liver Cancer. Hepatology, 2019 Jan; 69(1): 359-375.
  5. Li S, Zhang J, Huang S*, He X*. Genome-wide analysis reveals that exon methylation facilitates its selective usage in the human transcriptome. Brief Bioinform, 2018 Sep 28; 19(5): 754-764.
  6. Li Z, Zhang J, Liu X, Li S, Wang Q, Chen D, Hu Z, Yu T, Ding J, Li J, Yao M, Fan J, Huang S, Gao Q*, Zhao Y*, He X*. The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma. Nat Commun, 2018 Apr 20; 9(1): 1572.
  7. Wang H, Liang L, Dong Q, Huan L, He J, Li B, Yang C, Jin H, Wei L, Yu C, Zhao F, Li J, Yao M, Qin W*, Qin L*, He X*. Long noncoding RNA miR503HG, a prognostic indicator, inhibits tumor metastasis by regulating the HNRNPA2B1/NF-κB pathway in hepatocellular carcinoma. Theranostics, 2018 April 15; 8(10): 2814-2829.
  8. Guo W, Hu Z, Bao Y, Li Y, Li S, Zheng Q, Lyu D, Chen D, Yu T, Li Y, Zhu X, Ding J, Zhao Y, He X*, Huang S*. A LIN28B Tumor-Specific Transcript in Cancer. Cell Rep, 2018 Feb 20; 22(8): 2016-2025.
  9. Zhang J, Li Z, Liu L, Wang Q, Li S, Chen D, Hu Z, Yu T, Ding J, Li J, Yao M, Huang S, Zhao Y*, He X*. Long noncoding RNA TSLNC8 is a tumor suppressor that inactivates the interleukin-6/STAT3 signaling pathway. Hepatology, 2018 Jan; 67(1): 171-187.
  10. Chen Z, Lu X, Jia D, Jing Y, Chen D, Wang Q, Zhao F, Yao M, Cong W, He X*. Hepatic SMARCA4 predicts HCC recurrence and promotes tumour cell proliferation by regulating SMAD6 expression. Cell Death Dis, 2018 Jan 19; 9(2): 59.
  11. Yu T, Zhao Y, Hu Z, Li J, Chu D, Zhang J, Li Z, Chen B, Zhang X, Pan H, Li S, Lin H, Liu L, Yan M, He X*, Yao M*. MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway. Cancer Res, 2017 Nov 1; 77(21): 5782-5794.
  12. Zheng Q, Bao C, Guo W, Li S, Chen J, Chen B, Luo Y, Lyu D, Li Y, Shi G, Liang L, Gu J, He X*, Huang S*. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nat Commun, 2016 Apr 6; 7: 11215.
  13. Qiu Z, Guo W, Wang Q, Chen Z, Huang S, Zhao F, Yao M, Zhao Y*, He X*. MicroRNA-124 reduces the pentose phosphate pathway and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer cells. Gastroenterology, 2015 Nov; 49(6): 1587-1598.e11.
  14. Guo W, Qiu Z, Wang Z, Wang Q, Tan N, Chen T, Chen Z, Huang S, Gu J, Li J, Yao M, Zhao Y*, He X*. MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer. Hepatology, 2015 Oct; 62(4): 1132-44.
  15. Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X*, Huang S*. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Res, 2015 Aug; 25(8): 981-4.
  16. Bao C, Li Y, Huan L, Zhang Y, Zhao F, Wang Q, Liang L, Ding J, Liu L, Chen T, Li J, Yao M, Huang S*, He X*. NF-κB signaling relieves negative regulation by miR-194 in hepatocellular carcinoma by suppressing the transcription factor HNF-1α. Sci Signal, 2015 Jul 28; 8(387): ra75.
  17. Chen Z, Wang Z, Guo W, Zhang Z, Zhao F, Zhao Y, Jia D, Ding J, Wang H, Yao M, He X*. TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma. Oncogene, 2015 Jul 23; 34(30): 3946-56.
  18. Jia D, Dong R, Jing Y, Xu D, Wang Q, Chen L, Li Q, Huang Y, Zhang Y, Zhang Z, Liu L, Zheng S, Xia Q, Wang H*, Dong K*, He X*. Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex. Hepatology, 2014 Nov; 60(5): 1686-96.
  19. Gao Q, Zhao YJ, Wang XY, Guo WJ, Gao S, Wei L, Shi JY, Shi GM, Wang ZC, Zhang YN, Shi YH, Ding J, Ding ZB, Ke AW, Dai Z, Wu FZ, Wang H, Qiu ZP, Chen ZA, Zhang ZF, Qiu SJ, Zhou J*, He XH*, Fan J*. Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients. Gastroenterology, 2014 May; 146(5): 1397-407.
  20. Wang Q, Huang Z, Guo W, Ni S, Xiao X, Wang L, Huang D, Tan C, Xu Q, Zha R, Zhang J, Sheng W, He X*, Du X*. microRNA-202-3p inhibits cell proliferation by targeting ADP-ribosylation factor-like 5A in human colorectal carcinoma. Clin Cancer Res, 2014 Mar 1; 20(5): 1146-57.
  21. Jia D, Jing Y, Zhang Z, Liu L, Ding J, Zhao F, Ge C, Wang Q, Chen T, Yao M, Li J, Gu J, He X*. Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma. Cell Res, 2014 Feb; 24(2): 204-17.
  22. Ding J, Huang S, Wang Y, Tian Q, Zha R, Shi H, Wang Q, Ge C, Chen T, Zhao Y, Liang L, Li J, He X*. Genome-wide screening reveals that miR-195 targets the TNF-α/NF-κB pathway by down-regulating IκB kinase alpha and TAB3 in hepatocellular carcinoma. Hepatology, 2013 Aug; 58(2): 654-66.
  23. Ke G, Liang L, Yang JM, Huang X, Han D, Huang S, Zhao Y, Zha R, He X*, Wu X*. MiR-181a confers resistance of cervical cancer to radiation therapy through targeting the pro-apoptotic PRKCD gene. Oncogene, 2013 Jun 20; 32(25): 3019-27.
  24. Zheng B, Liang L, Huang S, Zha R, Liu L, Jia D, Tian Q, Wang Q, Wang C, Long Z, Zhou Y, Cao X, Du C, Shi Y*, He X*. MicroRNA-409 suppresses tumour cell invasion and metastasis by directly targeting radixin in gastric cancers. Oncogene, 2012 Oct 18; 31(42): 4509-16.
  25. Gao Q, Zhao YJ, Wang XY, Qiu SJ, Shi YH, Sun J, Yi Y, Shi JY, Shi GM, Ding ZB, Xiao YS, Zhao ZH, Zhou J*, He XH*, Fan J*. CXCR6 upregulation contributes to a proinflammatory tumor microenvironment that drives metastasis and poor patient outcomes in hepatocellular carcinoma. Cancer Res, 2012 Jul 15; 72(14): 3546-56.
  26. Ying Q, Liang L, Guo W, Zha R, Tian Q, Huang S, Yao J, Ding J, Bao M, Ge C, Yao M, Li J, He X*. Hypoxia-inducible microRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma. Hepatology, 2011 Dec; 54(6): 2064-75.
  27. Zheng B, Liang L, Wang C, Huang S, Cao X, Zha R, Liu L, Jia D, Tian Q, Wu J, Ye Y, Wang Q, Long Z, Zhou Y, Du C, He X*, Shi Y*. MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer. Clin Cancer Res, 2011 Dec 15; 17(24): 7574-83.
  28. Jia D, Wei L, Guo W, Zha R, Bao M, Chen Z, Zhao Y, Ge C, Zhao F, Chen T, Yao M, Li J, Wang H, Gu J, He X*. Genome-wide copy number analyses identified novel cancer genes in hepatocellular carcinoma. Hepatology, 2011 Oct; 54(4): 1227-36.
  29. Huang Z, Huang S, Wang Q, Liang L, Ni S, Wang L, Sheng W, He X*, Du X*. MicroRNA-95 promotes cell proliferation and targets sorting Nexin 1 in human colorectal carcinoma. Cancer Res, 2011 Apr 1; 71(7): 2582-9.
  30. Zhao Y, Wang X, Wang T, Hu X, Hui X, Yan M, Gao Q, Chen T, Li J, Yao M, Wan D, Gu J*, Fan J*, He X*. Acetylcholinesterase, a key prognostic predictor for hepatocellular carcinoma, suppresses cell growth and induces chemosensitization. Hepatology, 2011 Feb; 53(2): 493-503.
  31. Liang L, Wong CM, Ying Q, Fan DN, Huang S, Ding J, Yao J, Yan M, Li J, Yao M, Ng IO, He X*. MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2. Hepatology, 2010 Nov; 52(5): 1731-40.
  32. Huang S, Wu S, Ding J, Lin J, Wei L, Gu J, He X*. MicroRNA-181a modulates gene expression of zinc finger family members by directly targeting their coding regions. Nucleic Acids Res, 2010 Nov; 38(20):7211-8.
  33. Ding J, Huang S, Wu S, Zhao Y, Liang L, Yan M, Ge C, Yao J, Chen T, Wan D, Wang H, Gu J, Yao M, Li J, Tu H, He X*. Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA. Nat Cell Biol, 2010 Apr; 12(4): 390-9.
  34. Wu S, Huang S, Ding J, Zhao Y, Liang L, Liu T, Zhan R*, He X*. Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region. Oncogene, 2010 Apr 15; 29(15):2302-8.
  35. Yao J, Liang L, Huang S, Ding J, Tan N, Zhao Y, Yan M, Ge C, Zhang Z, Chen T, Wan D, Yao M, Li J, Gu J, He X*. MicroRNA-30d promotes tumor invasion and metastasis by targeting Galphai2 in hepatocellular carcinoma. Hepatology, 2010 Mar; 51(3): 846-56.
 
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