专职PI
雷群英 教授
教授,博士生导师
E-mail: qlei@fudan.edu.cn
 

  1993年获江西医学院学士学位,1999年获苏州医学院硕士学位,2002年获上海医科大学医学博士学位,之后在美国加州大学洛杉矶分校做博士后研究,2006年被复旦大学引进,担任复旦大学基础医学院教授和生物医学研究院(IBS)PI,博士生导师,2017至今任职于复旦大学IBS及复旦大学附属肿瘤医院教授,博士生导师。
  国家杰出青年获得者,长江特聘教授,国家重大科学研究计划项目首席科学家和万人计划入选者,享受政府特殊津贴专家。先后入选上海市科委"浦江人才"、教育部"新世纪优秀人才"、上海市卫生系统"优秀学科带头人"、上海市教委"曙光学者"、上海市优秀学术带头人、科技部中青年科技领军人才。获明治乳业生命科学杰出奖(2011)、教育部自然科学一等奖(第五,2012)和二等奖(第一,2014)、上海市三八红旗手(2012)、第十届中国青年女科学家奖(2013)、中国女医师协会五洲女子科技奖(2015)、普康奖教金(2015)、上海市自然科学牡丹奖(2015)、上海育才奖(2016)和上海市三八红旗手标兵(2016)等荣誉。
  研究方向为肿瘤代谢,蛋白质翻译后修饰及其生理病理效应。迄今以通讯作者/共同通讯作者在Cancer CellCell MetabolismMolecular CellJ.Clin. InvestNature Communi. 等发表论文60余篇。


研究领域:

  主要从事于肿瘤发生发展的分子机制研究,研究方向包括:
  1. 肿瘤代谢
  2. 蛋白质翻译后修饰及其生理病理效应


研究团队:



代表性论著:(*为通讯作者)

  1. Xia S, Lin R, Jin L, Zhao L, Kang HB, Pan Y, Liu S, Qian G, Qian Z, Konstantakou E, Zhang B, Dong JT, Chung YR, Abdel-Wahab O, Merghoub T, Zhou L, Kudchadkar RR, Lawson DH, Khoury HJ, Khuri FR, Boise LH, Lonial S, Lee BH, Pollack BP, Arbiser JL, Fan J*, Lei QY*, Chen J*. Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth. Cell Metabolism, 2017 Feb 7; 25(2):358-373. doi: 10.1016/j.cmet.2016.12.010. (Highlight by Nature)
  2. Zhang Y#, Xu YY#, Zhao XN, Ren F, Li JT, Yang HB, Zhang M, Li, Yao CB, Yin M*,Chen J*, Lei QY*.Acetylation targets HSD17B4 for degradation via CMA pathway in response to E1. Autophagy, 2017; Online.
  3. Wang YP*,Wang J,Gao X, Xu YY, Cheng JK*, Lei QY*. Arginine Methylation of MDH1 by CARM1 Inhibits Non-canonical Glutamine Metabolism and Suppresses Pancreatic Cancer. Molecular Cell, 2016; 64:673–687. (Highlight by Cancer Discovery)
  4. Gao X#, Lin SH#,Ren F, Li1 JT, Chen JJ, Yao CB,Yang HB,Jiang SX, Yan GQ, Wang D, Wang Y, Liu Y, Cai Z, Xu YY, Chen J, Yu W, Yang YP*, Lei QY*. Acetate Functions as an Epigenetic Metabolite to Promote Lipid Synthesis under Hypoxia. Nature Commun. 2016 Jun 30; 7:11960. doi: 10.1038/ncomms11960.
  5. Yang HB#., Xu YY#*., Zhao XN, Zou SW*., Zhang Y., Zhang M., Li JT, Ren F., Wang LY., Lei QY*. (2015) Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellular cancer. Nature Commun. 2015 Apr 30; 6:6973. doi: 10.1038/ncomms7973.
  6. Zhou, X#., Wang, SY#., Wang, Z., Feng, X., Liu, P., Lv, X-B., Li, F-L., Yu, F-x., Sun,YP., Yuan, HX., Zhu,HG., Xiong,Y*., Lei, QY*., Guan, KL*.(2015). Estrogen Activates TAZ via GPER in Invasive Ductal Breast Carcinoma. J Clin Invest2015 May; 125(5):2123-35.
  7. Zha, ZY., Han, XR., Matthew D. Smith, Liu, Y., Patrick M. Giguère, DraganaKopanja, PradipRaychaudhuri, David P. Siderovski, Guan, KL*., Lei, QY. *, and Xiong, Y*. A non-canonical function of Gβ as a subunit of E3 ligase in targeting GRK2 ubiquitylation. Molecular Cell, 2015 Jun 4; 58(5):794-803.
  8. Zhao D., Mo Y., Li MT., Zou SW., Cheng ZL., Sun Y-P., Xiong Y*., Guan KL*., Lei QY*. NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin Invest, 2014; 124(12):5453-65.
  9. Li T, Liu F, Feng X, Wang Z, Das I, Xu Y, Zhou X, Sun Y, Guan KL , Xiong Y, Lei QY*. Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal. J. Biol. Chem. 2014; 289(6):3775-85.
  10. Lv L#, Xu Y#, Zhao D, Li F, Wang W, Sasaki N, Jiang Y, Zhou X, Li T, Guan KL*, Lei QY* and Xiong Y*. Mitogenic and oncogenic stimulation of K433 acetylation promote PKM2 protein kinase activity and nuclear localization. Molecular Cell, 2013; 52, 340–352. Cover story Highlight by Nature Review Cancer and Cancer Discovery)
  11. Lin R#, Ren T#, Gao X, Zhou X, Li T, Xiong Y, Guan KL, Lei QY*. Acetylation Stabilizes ATP-citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth. Molecular Cell, 2013; 51:506–518.
  12. Zhao D#, Zou S#, Liu Y, Zhou X, Mo Y, Wang P, Xu Y, Dong B, Xiong Y*, Lei QY* and Guan KL*., Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer. Cancer Cell, 2013; 23:464-476.
  13. Huang, W., Lv, X., Liu, CY., Zha, ZY., Zhang, H., Jiang, Y., Xiong, Y., Lei, QY*, and Guan, KL*.The N-terminal phosphodegron targets TAZ for SCFβ-TrCP dependent degradation in response to PI3K inhibition. J. Biol. Chem. 2012; 287(31):26245-53.
  14. Zhou X, Li T, Feng X, Hsiang E, Xiong Y, Guan KL , Lei QY*. Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage. Biochem J. 2012; 441(1):227-36.
  15. Lv L, Li D, Zhao D, Lin R, Chu Y,Zhang H, Zha Z, Ying Liu, Li Z, Xu Y, Huang Y, Gang W, Xiong Y, Guan KL, and Lei QY*. Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth. Molecular Cell. 2011; 42:719-730.  Feature article ( Highlight by Molecular Cell and Science Signaling)
  16. Liu C, Lv X, Li T, Xu Y, Zhou X, Zhao S, Xiong Y, Lei QY*, and Guan KL*. PP1 Cooperates with ASPP2 to dephosphorylate and activate TAZ. J. Biol. Chem. 2011; 286(7):5558-66.
  17. Liu Y, Zha Z, Zhou X, Zhang H, Huang W, Zhao D, Li , Chan SW, Lim CJ, Hong WJ, Zhao S, Xiong Y, Lei QY*, and Guan KL* . The Hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCFβ-TrCP E3 ligase. J. Biol. Chem. 2010; 285:37159-37169.
  18. Zhang H, Liu C, Zha Z, Zhao B4, Yao J, Zhao S, Xiong Y, Lei, QY*, and Guan KL*. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J. Biol. Chem. 2009; 284(20):13355-62.
  19. Lei QY*, Zhang H, Zhao B, Zha Z, Pei X, Bai F, Zhao S, Xiong Y, Guan KL. TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway. Molecular and Cellular Biology, 2008; 28:2426-2436.
  20. Lei Q, Jiao J, Xin L, Chang CJ, Wang S, Gao J, Witte ON, Liu X, Wu H. NKX3.1 stabilizes p53, inhibits AKT activation and blocks prostate cancer initiation caused by PTEN loss. Cancer Cell, 2006; 9:367-378. 
 Invited Review
  1. Zhou X, Lei QY*. Regulation of TAZ in cancer. Protein Cell, 2016; 7(8):548-61.
  2. Zhou X, Wang Z, Huang W, Lei QY*. G protein-coupled receptors: bridging the gap from the extracellular signals to the Hippo pathway. Acta Biochim Biophys Sin (Shanghai). 2015; (1):10-5.
  3. Huang W, Wang Z, Lei QY*. Acetylation control of metabolic enzymes in cancer: an updated version. Acta Biochim Biophys Sin (Shanghai), 2014; 46(3):204-13.
  4. Lin R, Zhou X, Huang W, Zhao D, Lv L, Xiong Y, Guan KL, Lei QY*.Acetylation control of cancer cell metabolism. Curr Pharm Des. 2014; 0(15):2627-33.
  5. Zhao D, Li FL, Cheng ZL, Lei QY*. Impact of acetylation on tumor metabolism. Mol Cell Oncol. 2014, 1(3):e963452. 
  6. Zhao B, Lei QY*, Guan KL*. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Current Opinion Cell Biology, 2008; 20(6):638-46.
 
复旦大学肿瘤研究所 通讯地址: 东安路270号2号楼1312室 64175590-5312 Email:fuci2012@126.com
Copyright 2013 shca.org.cn All rights reserved. 复旦大学肿瘤研究所 版权所有