专职PI
柳素玲 研究员
研究员,博士生导师
E-mail: suling@fudan.edu.cn
 

  中国科学院“百人计划”入选者;中组部“青年千人计划”入选者;2013年获得国家自然科学基金委“优青”基金。1997年毕业于中国科学技术大学生物系并获得学士学位;2003年获美国俄亥俄州立大学博士学位;2003-2010年在美国密歇根大学癌症研究中心从事癌症干细胞博士后研究工作;2010-2012年任美国密歇根大学医学院助理教授。2005-2008年获美国苏珊-库门癌症基金会博士后奖,2006年获美国癌症协会默克学者奖,2010年获美国癌症协会苏珊-库门学者奖,2014年获得USCACA‐NFCR 学术奖。迄今为止,在PNAS、Cancer Res.、Stem Cell Reports、JCI、Cell Stem Cell、JCO等国际杂志上共发表论文51篇(18篇为第一或通讯作者),论文他引超过4600次。现任World Journal of Stem Cells和ISRN cell biology等国际期刊编委。共申请国际专利五项。自从2003年首次发现实体瘤干细胞(乳腺肿瘤干细胞)以来,一直致力于创建和优化乳腺肿瘤干细胞的体内外实验技术,建立起来的体内外模型现已被广大肿瘤干细胞研究者所采用;研究了多种信号传导通路、肿瘤微环境以及小分子RNA对乳腺肿瘤干细胞的自我更新和分化的调控,其研究成果对于乳腺癌的新型治疗提供了强有力的理论依据。


研究领域:

  1)乳腺肿瘤干细胞的异质性及分子分型研究;
  2)非编码RNA(MicroRNA)对肿瘤干细胞的调控;
  3)肿瘤微环境对肿瘤干细胞的调控;
  4)肿瘤干细胞的免疫调控;
  5)靶向肿瘤干细胞的新型治疗策略研究及药物开发


研究团队:



代表性论著:

  1. Liu, R., Shi, P., Nie, Z., Liang, H., Zhou, Z., Chen, W., Chen, H., Dong, C., Yang, R., Liu, S., Chen, C.* Mifepristone Suppresses Basal Triple-Negative Breast Cancer Stem Cells by Down-regulating KLF5 Expression. Theranostics, 2016 Feb 13; 6(4):533-544.
  2. Xu, B., Du, W.Q., Li, J.W., Hu, Y.L.*, Yang, L., Zhang, C.C., Li, G.Q., Lao, Z.X., Ni, J.C.,Chu, J.R., Wu, D.*, Liu, S., Sugioka, K. High efficiency integration of three-dimensional functional microdevices inside a microfluidic chip by using femtosecond laser multifoci parallel microfabrication. Scientific Reports, 2016 Jan 28; 6:19989. 
  3. Zhao, Z., Li, S., Song, E., and Liu, S*. The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells. Protein & cell, 2016 Feb; 7(2):89-99.
  4. Liu, Y., Chen, C., Qian, P., Lu, X., Sun, B., Zhang, X., Wang, L., Gao, X., Li, H., Chen, Z., Tang, J., Zhang, W., Dong, J., Bai, R., Lobie, P. E., Wu, Q., Liu, S., Zhang, H., Zhao, F., Wicha, M. S., Zhu, T., and Zhao, Y. Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor. Nature Communications, 2015 Jan 23; 6:5988.
  5. Ke, J.*, Zhao, Z., Hong, S.-H., Bai, S., He, Z., Malik, F., Xu, J., Zhou, L., Chen, W., Martin-Trevino, R., Wu, X., Lan, P., Yi, Y., Ginestier, C., Ibarra, I., Shang, L., McDermott, S., Luther, T., Clouthier, S. G., Wicha, M. S.*, and Liu, S*. Role of microRNA221 in regulating normal mammary epithelial hierarchy and breast cancer stem-like cells. Oncotarget, 2015 Feb 28; 6(6):3709-21.
  6. Sun, S., Liu, S., Duan, S. Z., Zhang, L., Zhou, H., Hu, Y., Zhou, X., Shi, C., Zhou, R., and Zhang, Z*. Targeting the c-Met/FZD8 Signaling Axis Eliminates Patient-Derived Cancer Stem-like Cells in Head and Neck Squamous Carcinomas. Cancer Research, 2014 Dec 15; 74(24):7546-59..
  7. Lombardi, S., Honeth, G., Ginestier, C., Shinomiya, I., Marlow, R., Buchupalli, B., Gazinska, P., Brown, J., Catchpole, S., Liu, S., Barkan, A., Wicha, M., Purushotham, A., Burchell, J., Pinder, S., and Dontu, G*. Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells. Stem Cell Reports, 2014 Jun 3; 2(6):780-93.
  8. Liu, S.*, Cong, Y., Wang, D., Sun, Y., Deng, L., Liu, Y., Martin-Trevino, R., Shang, L., McDermott, S. P., Landis, M. D., Hong, S., Adams, A., D'Angelo, R., Ginestier, C., Charafe-Jauffret, E., Clouthier, S. G., Birnbaum, D., Wong, S. T., Zhan, M., Chang, J.C.*, and Wicha, M.S.* Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts. Stem Cell Reports, 2013 Dec 27; 2(1):78-91.
  9. Ding, K., Banerjee, A., Tan, S., Zhao, J., Zhuang, Q., Li, R., Qian, P., Liu, S., Wu, Z.-S., Lobie, P. E., and Zhu, T*. Artemin, a Member of the Glial Cell Line-derived Neurotrophic Factor Family of Ligands, Is HER2-regulated and Mediates Acquired Trastuzumab Resistance by Promoting Cancer Stem Cell-like Behavior in Mammary Carcinoma Cells. Journal of Biological Chemistry, 2014 Jun 6; 289(23):16057-71. 
  10. Deng, L., Shang, L., Bai, S., Chen, J., He, X., Martin-Trevino, R., Chen, S., Li, X.-Y., Meng, X., Yu, B., Wang, X., Liu, Y., McDermott, S. P., Ariazi, A. E., Ginestier, C., Ibarra, I., Ke, J., Luther, T., Clouthier, S. G., Xu, L., Shan, G., Song, E., Yao, H., Hannon, G. J., Weiss, S. J., Wicha, M. S., and Liu, S*. MicroRNA100 Inhibits Self-Renewal of Breast Cancer Stem-like Cells and Breast Tumor Development. Cancer research, 2014 Nov 15; 74(22):6648-60.
  11. Luo, M., Zhao, X., Chen, S., Liu, S., Wicha, M. S., and Guan, J.-L.* Distinct FAK Activities Determine Progenitor and Mammary Stem Cell Characteristics. Cancer Research, 2013 Sep 1; 73(17):5591-602.
  12. Wu, J., Liu, S., Liu, G., Dombkowski, A., Abrams, J., Martin-Trevino, R., Wicha, M.S.*, Ethier, S. P., and Yang, Z.-Q. Identification and functional analysis of 9p24 amplified genes in human breast cancer. Oncogene, 2012 Jan 19; 31(3):333-41. 
  13. Liu, S.*, Patel, S. H., Ginestier, C., Ibarra, I., Martin-Trevino, R., Bai, S., McDermott, S. P., Shang, L., Ke, J., Ou, S. J., Heath, A., Zhang, K. J., Korkaya, H., Clouthier, S. G., Charafe-Jauffret, E., Birnbaum, D., Hannon, G. J., and Wicha, M.S*. MicroRNA93 Regulates Proliferation and Differentiation of Normal and Malignant Breast Stem Cells. Plos Genetics, 2012; 8(6):e1002751. 
  14. Liu, S., Korkaya, H., and Wicha, M.S.* ARE CANCER STEM CELLS READY FOR PRIME TIME? Scientist, 2012; 26:32-37.
  15. Liu, S., Clouthier, S. G., and Wicha, M.S.* Role of microRNAs in the Regulation of Breast Cancer Stem Cells. Journal of Mammary Gland Biology and Neoplasia, 2012; 17: 15-21.
  16. Liu, S.*, Ginestier, C., Ou, S. J., Clouthier, S. G., Patel, S. H., Monville, F., Korkaya, H., Heath, A., Dutcher, J., Kleer, C. G., Jung, Y., Dontu, G., Taichman, R., and Wicha, M.S.* Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks. Cancer Research, 2011 Jan 15; 71(2):614-24.
  17. Liu, S., and Wicha, M. S. Targeting Breast Cancer Stem Cells. Journal of Clinical Oncology, 2010; 28:4006-4012. PMID:20498387.
  18. Ginestier, C., Liu, S., Diebel, M. E., Korkaya, H., Luo, M., Brown, M., Wicinski, J., Cabaud, O., Charafe-Jauffret, E., Birnbaum, D., Guan, J.-L., Dontu, G., and Wicha, M. S. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. Journal of Clinical Investigation, 2010 Feb; 120(2):485-97.
  19. Ginestier, C., Liu, S., and Wicha, M. S. Getting to the Root of BRCA1-Deficient Breast Cancer. Cell Stem Cell, 2009 Sep 4; 5(3):229-30.
  20. Liu, S., Ginestier, C., Charafe-Jauffret, E., Foco, H., Kleer, C. G., Merajver, S. D., Dontu, G., and Wicha, M. S. BRCA1 regulates human mammary stem/progenitor cell fate. Proceedings of the National Academy of Sciences of the United States of America, 2008 Feb 5; 105(5):1680-5.
  21. Ginestier, C., Hur, M. H., Charafe-Jauffret, E., Monville, F., Dutcher, J., Brown, M., Jacquemier, J., Viens, P., Kleer, C. G., Liu, S., Schott, A., Hayes, D., Birnbaum, D., Wicha, M. S., and Dontu, G. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell, 2007 Nov; 1(5):555-67.
  22. Liu, S., Dontu, G., Mantle, I., Patel, S., Ahn, N., Jackson, K., Suri, P., and Wicha, M. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Research, 2006 Jun 15; 66(12):6063-71.


Book Chapters
  1. Xu, J., and Liu, S*. Non-coding RNAs in cancer cell plasticity. The long and shortnon-coding RNAs in cancer biology. Chapter 6, Page 137-172, 2016 (Springer).
  2. Ouzounova, M., Liu, S*. and Wicha, M.S. Stem Cells in Breast Development and Carcinogenesis: Concepts and Clinical Perspectives. Diseases of the breast, 5th edition, Chapter 2, Page 15-24, 2014.
  3. Liu, Y. and Liu, S*. Role of Cancer Stem Cell in Mammary Carcinogenesis and Its Clinical Implication. Stem Cells and Cancer Stem Cells Vol 10, 189-197, 2013.
  4. Mantle, I., Dontu, G., Liu, S*. and Wicha, M.S. Cancer stem cells: implications for development of more effective therapies. Cancer drug resistance, PART II: Biological Resistance. 2005.
 
复旦大学肿瘤研究所 通讯地址: 东安路270号2号楼1312室 64175590-5312 Email:fuci2012@126.com
Copyright 2013 shca.org.cn All rights reserved. 复旦大学肿瘤研究所 版权所有