专职PI

柳素玲 研究员
研究员,博士生导师
E-mail: suling@fudan.edu.cn
 


  柳素玲,复旦大学生物医学研究院和肿瘤医院双聘教授,博士研究生导师,中国科学院“百人计划”入选者;中组部“青年千人计划”入选者;国家优秀青年科学基金获得者。1997年毕业于中国科学技术大学生物系并获得学士学位;2003年获美国俄亥俄州立大学博士学位;2003-2010年在美国密歇根大学癌症研究中心从事癌症干细胞博士后研究工作;2010-2012年任美国密歇根大学医学院助理教授。2005-2008年获美国苏珊-库门癌症基金会博士后奖,2006年获美国癌症协会默克学者奖,2010年获美国癌症协会苏珊-库门学者奖,2014年获得USCACANFCR 学术奖,2018年获得中国肿瘤青年科学家奖, 2019年获得上海市医学领军人才称号。在Nature CommunicationsClinical Cancer Res.Plos BiologyCancer Res.PNASJCICell Stem CellJCO 等国际杂志上共发表论文66篇(20篇为通讯或共通讯作者,9篇为第一作者),论文他引超过7900次。作为独立研究PI,获得美国Susan G Komen Foundation研究资助;美国国防部(DOD)研究资助;美Astrazeneca/Medimmune公司研究资助;中国中共中组部“青年千人”计划资助;中国科学院干细胞与再生医学先导项目资助;国家自然科学基金委“优青”项目、重点项目和面上项目资助;获得科技部国家重点研发计划和973子课题项目资助。


研究领域:

  1)乳腺肿瘤干细胞的异质性及耐药研究;
  2)非编码RNA(MicroRNA)对肿瘤干细胞的调控;
  3)肿瘤微环境对肿瘤干细胞的调控;
  4)肿瘤干细胞的免疫调控;
  5)靶向肿瘤干细胞的新型治疗策略研究及药物开发。


研究团队:



代表性论著:

  1. Jin, X., Xu, X-E., Jiang, Y-Z., Liu, Y-R., Sun, W., Guo, Y-J., Ren, Y-X., Zuo, W-J., Hu, X., Huang, S-L., Shen, H-J., Lan, F., He, Y-F., Hu, G-H., Di, G-H., He, X-H., Li, D-Q., Liu, S.*, Yu, K-D.*,, Shao, Z-M.*. The endogenous retrovirus-derived long noncoding RNA TROJAN promotes triple-negative breast cancer progression via ZMYND8 degradation. Science Advances, 2019; 5: eaat9820.
  2. Cui, B., Luo, Y., Tian, P., Peng, F., Lu, J., Yang, Y., Su, Q., Liu, B., Yu, J., Luo, X., Yin, L., Cheng, W., An, F., He, B., Liang, D., Wu, S., Chu, P., Song, L., Liu, X., Luo, H., Xu, J., Pan, Y., Wang, Y., Li, D., Huang, P., Yang, Q., Zhang, L., Zhou, B.P., Liu, S., Xu, G.,  Lam, E.W.-F., Kelley, K.W. and Liu, Q.*. Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells. JCI ,2019 (online). PMID: 30688660.
  3. Liu, J., Duan, Z., Guo, W., Zeng, L., Wu, Y., Chen, Y., Tai, F., Wang, Y., Lin, Y., Zhang, Q., He, Y., Deng J., Stewart, R., Wang, C., Lin, P., Ghaffari, S., Evers, B.M., Liu, S.*, Zhou, M-M.*, Zhou, B.*, and Shi, J.*. Targeting the BRD4/FOXO3a/CDK6 axis Sensitizes AKT Inhibition in Luminal Breast Cancer. Nature Communications, 2018; 9(1): 5200. PMID: 30518851.
  4. Liu, B., Du, R., Zhou L., Xu, J., Chen, S., Chen, J., Yang, X., Liu, D-X., Shao, Z-M., Zhang, L., Yu, Z., Xie, N. *, Guan, J-L.*, and Liu, S.*. miR-200c/141 regulates breast cancer stem cell heterogeneity via targeting HIPK1/β-catenin axis. Theranostics, 2018; 8(21): 5801-5813.
  5. Deng, L., Gao, X., Liu, B., He, X., Xu, J., Qiang, J., Wu, Q., Liu, S.*. NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway. Cell Death and Disease, 2018; 9(12):1143. PMID: 30446635.
  6. Chen, L-L., Lin, H-P., Zhou, W-J., He, C-X., Zhang, Z-Y., Cheng, Z-L., Song, J-B., Liu, P., Chen, X-Y., Xia, Y-K., Chen, X-F., Sun, R-Q., Zhang, J-Y., Sun, Y-P., Song, L., Liu, B-J., Du, R-K., Ding, C., Lan, F., Huang, S-L., Zhou, F., Liu, S., Xiong, Y.*, Ye, D.*, Guan, K-L.*  SNIP1 recruits TET2 to regulate c-MYC target genes and cellular DNA damage response. Cell Reports, 2018; 25(6):1485-1500. PMID: 30404004.
  7. Chen, W., Qin, Y., Wang, D., Zhou, L., Liu, Y., Chen, S., Yin, L., Xiao, Y., Yao, X-H., Yang, X., Ma, W., Chen, W., He, X., Zhang, L., Yang, Q., Bian, X., Shao, Z-M., Liu, S.* CCL20 triggered by chemotherapy hinders the therapeutic efficacy of breast cancer. Plos Biology, 2018; 16(7): e2005869. PMID: 30052635.
  8. Chen, F., Long, Q., Fu, D., Zhu, D., Ji, Y., Han, L., Zhang, B., Xu, Q., Liu, B., Li, Y., Wu, S., Yang, C., Qian, M., Xu, J., Liu, S., Cao, L., Chin, E.Y., Lam, E.W.F., Coppé, J-P., Sun, Y. Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance. Nature Communications, 2018; 9: 4315.
  9. Liu, M., Liu, Y., Deng, L., Wang, D., He, X., Zhou, L., Wicha, M.S., Bai, F.*, Liu, S.*.Transcriptional profiles of different states of cancer stem cells in triple-negative breast cancer. Mol Cancer, 2018; 17(1): 65. PMID: 29471829.
  10. Du, R., Liu, B., Zhou, L., Wang, D., He, X., Xu, X., Zhang, L., Niu, C.*, Liu, S.*. Downregulation of annexin A3 inhibits tumor metastasis and decreases drug resistance in breast cancer. Cell Death and Disease, 2018; 9(2): 126. PMID: 29374148.
  11. Wang, D., Xu, J., Liu, B., He, X., Zhou, L., Hu, X., Qiao, F., Zhang, A., Xu, X., Zhang, H., Wicha, MS., Zhang, L., Shao, Z., Liu, S.*. IL6 blockade potentiates the anti-tumor effects of γ-secretase inhibitors in Notch3-expressing breast cancer. Cell Death and Differentiation, 2018; 25(2): 330-339,. PMID: 29027990.
  12. Qin, Y., Chen, W., Liu, B., Zhou, L., Deng, L., Niu, W., Bao, D., Cheng, C., Li, D., Liu, S.*, Niu, C.*. MiR-200c Inhibits the Tumor Progression of Glioma via Targeting Moesin. Theranostics, 2017; 7(6): 1663-1673.
  13. Zhang, Y.Y. Li,C., Yao, G.F., Du, L.J., Liu, Y., Zheng, X.J., Yan, S., Sun, J.Y., Liu, Y., Liu, M.Z., Zhang, X., Wei, G., Tong, W., Chen, X., Wu, Y., Sun, S., Liu, S., Ding, Q., Yu, Y., Yin, H., Duan, S.Z.. Deletion of Macrophage Mineralocorticoid Receptor Protects Hepatic Steatosis and Insulin Resistance Through ERα/HGF/Met Pathway. Diabetes, 2017; 66(6): 1535-1547. PMID: 28325853.
  14. Wang, D., Du, R., Liu, S.Rad51 inhibition sensitizes breast cancer stem cells to PARP inhibitor in triple-negative breast cancer.  Chin J Cancer, 2017; 36(1): 37. PMID: 2835929.
  15. Xu, J., Liu, S.*. Research progress in breast cancer stem cells. Scientia Sinica Vitae, 2017.
  16. Liu, Y., Burness, M.L., Martin-Trevino, R., Guy, J., Bai, S., Harouaka, R., Brooks, M.D., Shang, L., Fox, A., Luther, T.K., Davis, A., Baker, T.L., Colacino, J., Clouthier, S.G., Shao, Z-M., Wicha, M.S., and Liu, S*. RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer. Clinical Cancer Research, 2017; 23(2): 514-522.
  17. Liu, R., Shi, P., Nie, Z., Liang, H., Zhou, Z., Chen, W., Chen, H., Dong, C., Yang, R., Liu, S., Chen, C.* Mifepristone Suppresses Basal Triple-Negative Breast Cancer Stem Cells by Down-regulating KLF5 Expression. Theranostics, 2016 Feb 13; 6(4):533-544.
  18. Xu, B., Du, W.Q., Li, J.W., Hu, Y.L.*, Yang, L., Zhang, C.C., Li, G.Q., Lao, Z.X., Ni, J.C.,Chu, J.R., Wu, D.*, Liu, S., Sugioka, K. High efficiency integration of three-dimensional functional microdevices inside a microfluidic chip by using femtosecond laser multifoci parallel microfabrication. Scientific Reports, 2016 Jan 28; 6:19989.
  19. Zhao, Z., Li, S., Song, E., and Liu, S*. The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells. Protein & cell, 2016 Feb; 7(2):89-99.
  20. Liu, Y., Chen, C., Qian, P., Lu, X., Sun, B., Zhang, X., Wang, L., Gao, X., Li, H., Chen, Z., Tang, J., Zhang, W., Dong, J., Bai, R., Lobie, P. E., Wu, Q., Liu, S., Zhang, H., Zhao, F., Wicha, M. S., Zhu, T., and Zhao, Y. Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor. Nature Communications, 2015 Jan 23; 6:5988.
  21. Ke, J.*, Zhao, Z., Hong, S.-H., Bai, S., He, Z., Malik, F., Xu, J., Zhou, L., Chen, W., Martin-Trevino, R., Wu, X., Lan, P., Yi, Y., Ginestier, C., Ibarra, I., Shang, L., McDermott, S., Luther, T., Clouthier, S. G., Wicha, M. S.*, and Liu, S*. Role of microRNA221 in regulating normal mammary epithelial hierarchy and breast cancer stem-like cells. Oncotarget, 2015 Feb 28; 6(6):3709-21.
  22. Sun, S., Liu, S., Duan, S. Z., Zhang, L., Zhou, H., Hu, Y., Zhou, X., Shi, C., Zhou, R., and Zhang, Z*. Targeting the c-Met/FZD8 Signaling Axis Eliminates Patient-Derived Cancer Stem-like Cells in Head and Neck Squamous Carcinomas. Cancer Research, 2014 Dec 15; 74(24):7546-59.
  23. Lombardi, S., Honeth, G., Ginestier, C., Shinomiya, I., Marlow, R., Buchupalli, B., Gazinska, P., Brown, J., Catchpole, S.,Liu, S., Barkan, A., Wicha, M., Purushotham, A., Burchell, J., Pinder, S., and Dontu, G*. Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells.Stem Cell Reports, 2014 Jun 3; 2(6):780-93.
  24. Liu, S.* #, Cong, Y., Wang, D., Sun, Y., Deng, L., Liu, Y., Martin-Trevino, R., Shang, L., McDermott, S. P., Landis, M. D., Hong, S., Adams, A., D'Angelo, R., Ginestier, C., Charafe-Jauffret, E., Clouthier, S. G., Birnbaum, D., Wong, S. T., Zhan, M., Chang, J.C.*, and Wicha, M.S.* Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts. Stem Cell Reports, 2013 Dec 27; 2(1):78-91.
  25. Ding, K., Banerjee, A., Tan, S., Zhao, J., Zhuang, Q., Li, R., Qian, P., Liu, S., Wu, Z.-S., Lobie, P. E., and Zhu, T*. Artemin, a Member of the Glial Cell Line-derived Neurotrophic Factor Family of Ligands, Is HER2-regulated and Mediates Acquired Trastuzumab Resistance by Promoting Cancer Stem Cell-like Behavior in Mammary Carcinoma Cells.Journal of Biological Chemistry, 2014 Jun 6; 289(23):16057-71.
  26. Deng, L., Shang, L., Bai, S., Chen, J., He, X., Martin-Trevino, R., Chen, S., Li, X.-Y., Meng, X., Yu, B., Wang, X., Liu, Y., McDermott, S. P., Ariazi, A. E., Ginestier, C., Ibarra, I., Ke, J., Luther, T., Clouthier, S. G., Xu, L., Shan, G., Song, E., Yao, H., Hannon, G. J., Weiss, S. J., Wicha, M. S., and Liu, S*. MicroRNA100 Inhibits Self-Renewal of Breast Cancer Stem-like Cells and Breast Tumor Development. Cancer research, 2014 Nov 15; 74(22):6648-60.
  27. Luo, M., Zhao, X., Chen, S., Liu, S., Wicha, M. S., and Guan, J.-L.* Distinct FAK Activities Determine Progenitor and Mammary Stem Cell Characteristics. Cancer Research, 2013 Sep 1; 73(17):5591-602.
  28. Wu, J., Liu, S., Liu, G., Dombkowski, A., Abrams, J., Martin-Trevino, R., Wicha, M.S.*, Ethier, S. P., and Yang, Z.-Q. Identification and functional analysis of 9p24 amplified genes in human breast cancer. Oncogene, 2012 Jan 19; 31(3):333-41.
  29. Liu, S.* #, Patel, S. H., Ginestier, C., Ibarra, I., Martin-Trevino, R., Bai, S., McDermott, S. P., Shang, L., Ke, J., Ou, S. J., Heath, A., Zhang, K. J., Korkaya, H., Clouthier, S. G., Charafe-Jauffret, E., Birnbaum, D., Hannon, G. J., and Wicha, M.S*. MicroRNA93 Regulates Proliferation and Differentiation of Normal and Malignant Breast Stem Cells. Plos Genetics, 2012; 8(6):e1002751.
  30. Liu, S. #, Korkaya, H., and Wicha, M.S.* ARE CANCER STEM CELLS READY FOR PRIME TIME? Scientist, 2012; 26:32-37.
  31. Liu, S. #, Clouthier, S. G., and Wicha, M.S.* Role of microRNAs in the Regulation of Breast Cancer Stem Cells. Journal of Mammary Gland Biology and Neoplasia, 2012; 17: 15-21.
  32. Liu, S.* #, Ginestier, C., Ou, S. J., Clouthier, S. G., Patel, S. H., Monville, F., Korkaya, H., Heath, A., Dutcher, J., Kleer, C. G., Jung, Y., Dontu, G., Taichman, R., and Wicha, M.S.* Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks. Cancer Research, 2011 Jan 15; 71(2):614-24.
  33. Liu, S. #, and Wicha, M. S. Targeting Breast Cancer Stem Cells. Journal of Clinical Oncology, 2010; 28:4006-4012. PMID:20498387.
  34. Ginestier, C., Liu, S., Diebel, M. E., Korkaya, H., Luo, M., Brown, M., Wicinski, J., Cabaud, O., Charafe-Jauffret, E., Birnbaum, D., Guan, J.-L., Dontu, G., and Wicha, M. S. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. Journal of Clinical Investigation, 2010 Feb; 120(2):485-97.
  35. Ginestier, C., Liu, S., and Wicha, M. S. Getting to the Root of BRCA1-Deficient Breast Cancer. Cell Stem Cell, 2009 Sep 4; 5(3):229-30.
  36. Liu, S. #, Ginestier, C., Charafe-Jauffret, E., Foco, H., Kleer, C. G., Merajver, S. D., Dontu, G., and Wicha, M. S. BRCA1 regulates human mammary stem/progenitor cell fate. Proceedings of the National Academy of Sciences of the United States of America, 2008 Feb 5; 105(5):1680-5.
  37. Ginestier, C., Hur, M. H., Charafe-Jauffret, E., Monville, F., Dutcher, J., Brown, M., Jacquemier, J., Viens, P., Kleer, C. G.,Liu, S., Schott, A., Hayes, D., Birnbaum, D., Wicha, M. S., and Dontu, G. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell, 2007 Nov; 1(5):555-67.
  38. Liu, S. #, Dontu, G., Mantle, I., Patel, S., Ahn, N., Jackson, K., Suri, P., and Wicha, M. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Research, 2006 Jun 15; 66(12):6063-71.


Book Chapters
  1. Xu, J., and Liu, S*. Non-coding RNAs in cancer cell plasticity. The long and shortnon-coding RNAs in cancer biology. Chapter 6, Page 137-172, 2016 (Springer).
  2. Ouzounova, M., Liu, S*. and Wicha, M.S. Stem Cells in Breast Development and Carcinogenesis: Concepts and Clinical Perspectives. Diseases of the breast, 5th edition, Chapter 2, Page 15-24, 2014.
  3. Liu, Y. and Liu, S*. Role of Cancer Stem Cell in Mammary Carcinogenesis and Its Clinical Implication. Stem Cells and Cancer Stem Cells Vol 10, 189-197, 2013.
  4. Mantle, I., Dontu, G., Liu, S*. and Wicha, M.S. Cancer stem cells: implications for development of more effective therapies. Cancer drug resistance, PART II: Biological Resistance. 2005.
 
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