专职PI
金伟 研究员
研究员,博士生导师
E-mail: jinwei7207@163.com
 

  2006年9月回国来到肿瘤医院乳腺癌研究所工作。作为课题负责人,主持了多项国家自然科学基金、教育部新世纪优秀人才基金、上海市浦江人才计划基金、上海市教委科研创新项目、教育部留学回国人员启动基金、上海市自然科学基金等多项省部级基金;作为骨干研究人员,参加了二项国家973项目和一项国家863项目的研究。已在国内外期刊杂志上发表论文60余篇,其中SCI论文40余篇,论文发表于Cancer Research、Oncotarget、Tumor Biology、PLOS ONE、J Biol Chem、Mol Cell Biol、Breast Cancer Res Treat、Biochem Pharmacol等学术杂志。目前正独立培养博士研究生3名,硕士研究生1名,联合培养硕士研究生1名。已培养硕士生2名,积累了较为丰富的实验室带教经验。


研究领域:

  主要从事乳腺癌转移相关的研究,目前主要研究方向包括:
  1.线粒体相关基因在乳腺癌转移中的作用;
  2.转录因子与乳腺癌发生发展的研究。


研究团队:

  研究助理:孙荷芬
  博士研究生:高水平、傅文燕
  硕士研究生:李良东
  联合培养硕士研究生:杨立鹏


代表性论著:

  1. Jiang HL#, Sun HF#, Gao SP, Li LD, Huang S, Hu X, Liu S, Wu J, Shao ZM, Jin W*. SSBP1 Suppresses TGFβ-Driven Epithelial-to-Mesenchymal Transition and Metastasis in Triple-Negative Breast Cancer by Regulating Mitochondrial Retrograde Signaling. Cancer Res, 2016 Feb 15; 76(4):952-64.
  2. Gao SP#, Sun HF#, Jiang HL, Li LD, Hu X, Xu XE, Jin W*. Loss of TIM50 suppresses proliferation and induces apoptosis in breast cancer. Tumour Biol, 2016 Jan; 37(1):1279-87. 
  3. Jiang HL#, Sun HF#, Gao SP, Li LD, Hu X, Wu J*, Jin W*. Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-β/SMAD signaling. Oncotarget, 2015 Jun 30; 6(18):16352-65.
  4. Gao SP#, Sun HF#, Jiang HL, Li LD, Hu X, Xu XE, Jin W*. Loss of COX5B inhibits proliferation and promotes senescence via mitochondrial dysfunction in breast cancer. Oncotarget, 2015 Dec 22; 6(41):43363-74.
  5. Li LD#, Sun HF#, Liu XX#, Gao SP, Jiang HL, Hu X, Jin W*. Down-Regulation of NDUFB9 Promotes Breast Cancer Cell Proliferation, Metastasis by Mediating Mitochondrial Metabolism. PLoS One, 2015 Dec 7; 10(12):e0144441.
  6. Wei Jin#, Bo-bin Chen, Ji-yu Li, Hua Zhu, Mark Huang, Sheng-mei Gu, Qiao-qiao Wang, Jia-ying Chen, Sanjian Yu, Jiong Wu, Zhi-ming Shao*. TIEG1 inhibits breast cancer invasion and metastasis by inhibition of EGFR transcription and the EGFR signaling pathway. Mol Cell Biol, 2011; 32(1):50-63.
  7. Wei Jin#, Li Chen, Ying Chen, Si-guang Xu, Gen-hong Di, Wen-jin Yin, Jiong Wu, Zhi-ming Shao. UHRF1 is associated with epigenetic silencing of BRCA1 in sporadic breast cancer. Breast Cancer Res Treat, 2010; 123(2):359-73.
  8. Cao AY#, Jin W#, Shi PC, Di GH, Shen ZZ, Shao ZM*. Identification and characterization of two novel germ line p53 mutations in the non-LFS/non-LFL breast cancer families in Chinese population. Breast Cancer Res Treat, 2010 Jan; 119(2):295-303. (co-first)
  9. Jin W#, Chen Y, Di GH, Miron P, Hou YF, Gao H, Shao ZM*. P53 attenuates ERα-mediated transcriptional activation on the BRCA2 promoter. J Biol Che, 2008; 283(44):29671-29680.
  10. Jin W#, Di G, Li J, Chen Y, Li W, Wu J, Cheng T, Yao M, Shao Z*. TIEG1 induces apoptosis through mitochondrial apoptotic pathway and promotes apoptosis induced by homoharringtonine and velcade. FEBS Lett, 2007; 581(20):3826-32.
 
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