专职PI
赵莹珺 副研究员
副研究员,博士
E-mail: zhaoyingjun@fudan.edu.cn
 

  2001年获武汉大学理学学士学位,2005年获复旦大学病原生物学硕士学位,2010年获复旦大学病原生物学博士学位,2005-2013年在上海市肿瘤研究所癌基因及相关基因国家重点实验室工作,从事肿瘤基因组学及细胞信号转导通路等方面的研究工作。2013年10月任职于复旦大学生物医学研究院和复旦大学附属肿瘤医院肿瘤研究所,副研究员。


研究领域:

  肝癌基因组学,表观遗传学
  从事肿瘤相关基因功能及细胞信号转导和肿瘤功能基因组学等研究,研究microRNA及lncRNA 调控网络及其应用基础。2011 年以来,围绕“肝癌功能基因组学”,研究参与肝癌相关的转录调控及转录后调控的重要RNA、蛋白分子的功能及临床意义,取得了一系列原创性科研成果。


代表性论著:

  1. Qiu Zhaoping#, Guo Weijie#, Wang Qifeng#, Chen Zhiao, Huang Shenglin, Zhao Fangyu, Yao Ming, Zhao Yingjun*, He Xianghuo*. MicroRNA-124 reduces the pentose phosphate pathway and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer cells. Gastroenterology, 2015; 149(6):1587-1598.e11.
  2. Guo Weijie#, Qiu Zhaoping#, Wang Zhichao#, Wang Qifeng, Tan Ning, Chen Taoyang, Chen Zhiao, Huang Shenglin, Gu Jianren, Li Jinjun, Yao Ming, Zhao Yingjun*, He Xianghuo*. MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer. Hepatology, 2015; 62(4):1132-1144.
  3. Gao Qiang#, Zhao Ying-Jun#, Wang Xiao-Ying#, Guo Wei-Jie, Gao Song, Wei Lin, Shi Jie-Yi, Shi Guo-Ming, Wang Zhi-Chao, Zhang Yuan-Nv, Shi Ying-Hong, Ding Jie, Ding Zhen-Bin, Ke Ai-Wu, Dai Zhi, Wu Fei-Zhen, Wang Hui, Qiu Zhao-Ping, Chen Zhi-Ao, Zhang Zhen-Feng, Qiu Shuang-Jian, Zhou Jian*, He Xiang-Huo*, Fan Jia*. Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients. Gastroenterology, 2014; 146(5): 1397-1407.
  4. Gao Qiang#, Zhao Ying-Jun#, Wang Xiao-Ying#, Qiu Shuang-Jian, Shi Ying-Hong, Sun Jian, Yi Yong, Shi Jie-Yi, Shi Guo-Ming, Ding Zhen-Bin, Xiao Yong-Sheng, Zhao Zhong-Hua, Zhou Jian*, He Xiang-Huo*, Fan Jia*. CXCR6 upregulation contributes to a proinflammatory tumor microenvironment that drives metastasis and poor patient outcomes in hepatocellular carcinoma. Cancer Research, 2012; 72(14):3546-3556.
  5. Zhao Yingjun#, Wang Xiaoying#, Wang Tao, Hu Xin, Hui Xin, Yan Mingxia, Gao Qiang, Chen Taoyang, Li Jinjun, Yao Ming, Wan Dafang, Gu Jianren*, Fan Jia*, He Xianghuo*. Acetylcholinesterase, a key prognostic predictor for hepatocellular carcinoma, suppresses cell growth and induces chemosensitization. Hepatology, 2011; 53(2):493-503.
 
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