临床PI
蔡三军 教授
教授,博士生导师
E-mail: caisanjuncsj@163.com
 

  复旦大学附属肿瘤医院大肠癌多学科协作组首席专家、复旦大学大肠癌诊治中心主任、上海市抗癌协会大肠癌专业委员会主任委员、中国抗癌协会大肠癌专业委员会前主任委员、美国临床肿瘤指南(NCCN)中国版专家委员会委员、NCCN大肠癌临床实践指南(中国版)外科执笔人、主要从事结直肠癌基础和临床研究,尤其擅长于大肠癌的手术治疗,是中国著名的大肠癌专家。主编《结直肠肛门肿瘤》,北京大学出版社2005年;《循证结直肠肛管肿瘤学》,上海科学技术出版社2015年。近5年发表医学论文70余篇,其中SCI 50余篇,2012获得上海市科学技术及教育部科技进步二等奖,第一完成人。先后参与承担国自然、国家863、973、复旦211等重大科研课题,累计经费2300余万。


研究领域:

  从事腹部肿瘤外科35年,重点从事大肠癌、胃癌、软组织腹膜后肿瘤、恶性黑色素瘤的临床及基础研究,对局部晚期的大肠癌以及复发转移的大肠癌的综合治疗具有非常丰富的经验。注重临床工作,具有扎实的基本理论、基本技术和技巧;具有广泛的肿瘤学知识和临床经验,提出:手术切除的肿瘤根治性和姑息性手术的处理原则;肿瘤手术的无瘤、无菌、无血、微创的操作原则;对无瘤操作、电刀使用、根治规范上有新的发展;对大肠癌、胃癌、软组织腹膜后肿瘤、恶性黑色素瘤的诊治达到国内外先进水平;自1983年起参加肿瘤手术超过13000例,其中主刀胃癌手术超过3600例,大肠癌手术7000例,近3年每年大肠癌手术650-700例。


研究团队:

  自2005年来担任复旦大学大肠癌中心主委、肿瘤医院大肠癌多学科协作组首席科学家,对大肠癌诊治方面的各种治疗方式、综合治疗、个体化治疗有较深的理解,形成了国内最好的大肠癌MDT队伍,团队包括大肠外科、放疗科、肿瘤内科、病理科、放射诊断、内镜科、肝外科、介入科及中医科,积极推动了国内大肠癌的规范性多学科综合治疗的发展。


代表性论著:

  1. Xiang Hu# , Ya-Qi Li, Qing-Guo Li, Yan-Lei Ma, Jun-Jie Peng and San-Jun Cai*. Radiotherapy for stage IIA rectal cancer may not benefit all. Oncotarget, 2017; 8 (59):99438-99450.
  2. Qingguo Li#, Yaqi Li, Junyan Xu, Sheng Wang, Ye Xu , Xinxiang Li, Sanjun Cai*. Aldolase B Overexpression is Associated with Poor Prognosis and Promotes Tumor Progression by Epithelial-Mesenchymal Transition in Colorectal Adenocarcinoma. Cell Physiol Biochem, 2017; 42(1):397-406.
  3. Qingguo Li#, Weixing Dai, Yaqi Li, Ye Xu, Xinxiang Li & Sanjun Cai*. Nomograms for predicting the  prognostic value of serological tumor biomarkers in colorectal cancer patients after radical resection. Sci Rep, 2017 Apr 18; 7:46345.
  4. Qingguo Li#, Changjian Wang, Yaqi Li, Xinxiang Li, Ye Xu, Guoxiang Cai, Peng Lian and Sanjun Cai*. Lymph node status as a prognostic factor after palliative resection of primary tumor for patients with metastatic colorectal cancer. Oncotarget, 2017 Jul 18; 8(29):48333-48342.
  5. Ben Huang#, Chen Chen, Mengdong Ni, Xiaomin Xue, Guoxiang Cai, Sanjun Cai*.The association between small tumor size and poor survival in T4 mucinous adenocarcinoma of colon  without distant metastasis. J BUON, 2017 Jan-Feb; 22(1):170-177.
  6. Yongzhi Yang#,Wenhao Weng,Junjie Peng, Leiming Hong, Lei Yang,Yuji Toiyama, Renyuan Gao, Minfeng Liu, Mingming Yin, Cheng Pan, Hao Li, Bomin Guo, Qingchao Zhu, Qing Wei, Mary-Pat Moyer, Ping Wang, Sanjun Cai*, Ajay Goel, Huanlong Qin, and Yanlei Ma*.Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear FactorLkB, and Up-regulating Expression of MicroRNA-21. Gastroenterology, 2017 Mar; 152(4):851-866.
  7. Debing Shi#, Lei Liang, Hongtu Zheng, Guoxiang Cai , Xinxiang Li , Ye Xu ,Sanjun Cai*. Silencing of long non-coding RNA SBDSP1 suppresses tumor growth and invasion in colorectal cancer.  Biomed Pharmacother, 2017 Jan; 85:355-361.
  8. Qingguo Li#, Yaqi Li , Weixing Dai, Sheng Wang , Ye Xu , Xinxiang Li and Sanjun Cai*. Adjuvant radiotherapy improves cause specific survival in stage II, not stage III mucinous carcinoma of the rectum. BMC Cancer, 2017 Jan 26; 17(1):80.
  9. Ben Huang#, Mengdong Ni, Chen Chen, Guoxiang Cai, Sanjun Cai*. LODDS is superior to lymph node ratio for the prognosis of node-positive rectal cancer patients treated with preoperative radiotherapy. Tumori, 2017 Jan 21; 103(1):87-92.
  10. Yi-Wei Li#, Peng Lian , Ben Huang , Hong-Tu Zheng, Ming-He Wang, Wei-Lie Gu, Xin-Xiang Li, Ye Xu & San-Jun Cai*. Very Early Colorectal Anastomotic Leakage within 5 Post-operative Days: a More Severe Subtype Needs Relaparatomy. Sci Rep, 2017 Jan 13; 7:39936.
  11. Ben Huang#, Shaobo Mo , Mengdong Ni, Chen Chen, Guoxiang Cai, Sanjun Cai*. Comparison of survival and pathological features of signet-ring cell carcinoma of the colon between young and elderly patients. Int J Clin Exp Pathol, 2016; 9(11):11736-11743.
  12. Ben Huang#, Mengdong Ni, Chen Chen, Yang Feng, and Sanjun Cai*. Younger Age Is Associated with Poorer Survival in Patients with Signet-Ring Cell Carcinoma of the Colon without Distant Metastasis. Gastroenterol Res Pract, 2016; 2016:2913493.
  13. Fangqi Liu# , Li Yang, Yuchen Wu, Cong Li, Jiang Zhao, Adili Keranmu , Hongtu Zheng ,Dan Huang, Lei Wang, Tong Tong, Junyan Xu , Ji Zhu, Sanjun Cai*, Ye Xu. CapOX as neoadjuvant chemotherapy for locally advanced operable colon cancer patients: a prospective single-arm phase II trial. Chin J Cancer Res, 2016 Dec; 28(6):589-597.
  14. Hu Jinsong#, Cai Guoxiang, Xu Ye, Cai Sanjun*. The plasma microRNA miR-1914* and -1915 Suppresses Chemoresistant in Colorectal Cancer Patients by Down-Regulating NFIX. Curr Mol Med, 2016; 16(1):70-82.
  15. Qingguo Li#, Ping Wei, Ben Huang, Ye Xu, Xinxiang Li, Yaqi Li, Sanjun Cai* and Dawei Li*. MAEL expression links epithelial-mesenchymal transition and stem cell properties in colorectal cancer. Int J Cancer, 2016 Dec 1; 139(11):2502-11.
  16. Ben Huang#, Chen Chen , Mengdong Ni, Shaobo Mo, Guoxiang Cai*, Sanjun Cai*. Log odds of positive lymph nodes is a superior prognostic indicator in stage III rectal cancer patients: A retrospective analysis of 17,632 patients in the SEER database. International Journal of Surgery, 2016; 32:24-33.
  17. Qingguo Li#, Yi Qin, Ping Wei, Peng Lian, Yaqi Li, Ye Xu, Xinxiang Li,Dawei Li*, and Sanjun Cai*. Gas1 Inhibits Metastatic and Metabolic Phenotypes in Colorectal Carcinoma. Mol Cancer Res, 2016 Sep; 14(9):830-40.
  18. Qingguo Li#, Lei Liang, Huixun Jia, Xinxiang Li, Ye Xu, Ji Zhu and Sanjun Cai*. Negative to positive lymph node ratio is a superior predictor than traditional lymph node status in stage III colorectal cancer. Oncotarget, 2016 Nov 1; 7(44):72290-72299.
  19. Yaqi Li#, Lei Liang, Weixing Dai, Guoxiang Cai, Ye Xu, Xinxiang Li, Qingguo Li and Sanjun Cai*. Prognostic impact of programed cell death-1 (PD-1) and PD-ligand 1 (PD-L1) expression in cancer cells and tumor infiltrating lymphocytes in colorectal cancer. Molecular Cancer, 2016 Aug 24; 15(1):55.
  20. Yaqi Li#, Huixun Jia, Wencheng Yu, Ye Xu, Xinxiang Li, Qingguo Li* and Sanjun Cai*. Nomograms for predicting prognostic value of inflammatory biomarkers in colorectal cancer patients after radical resection. Int J Cancer, 2016; 139: 220–231.
  21. Sheng Wang#, Qin Zhang, Peng Yang, Xiangrong Yu, Li-Yong Huang,Shun Shen, Sanjun Cai*. Manganese Oxide-Coated Carbon Nanotubes As Dual-Modality Lymph Mapping Agents for Photothermal Therapy of Tumor Metastasis. ACS Applied Materials & Interfaces, 2016; 8(6):3736-41.
  22. Jinsong Hu#, Ye Xu and Sanjun Cai*. Specific microRNAs as novel biomarkers for combination chemotherapy resistance detection of colon adenocarcinoma. Eur J Med Res, 2015 Dec 2; 20:95.
  23. Debing Shi#, Guoxiang Cai, Junjie Peng, Dawei Li, Xinxiang Li, Ye Xu* and Sanjun Cai*. The preoperative SUVmax for (18)F-FDG uptake predicts survival in patients with colorectal cancer. BMC Cancer, 2015; 15:991.
  24. Qingguo Li#, Lei Liang, Lu Gan, Guoxiang Cai, Xinxiang Li, Sanjun Cai*. Effect of Lymph Node Count on Pathological Stage III Rectal Cancer with Preoperative Radiotherapy. Scientific Reports, 2015; 5:16990.
  25. Qingguo Li#, Xianke Meng, Lei Liang, Ye Xu, Guoxiang Cai, Sanjun Cai*. High preoperative serum globulin in rectal cancer treated with neoadjunctive chemoradiation therapy is a risk factor for poor outcome. Am J Cancer Res, 2015; 5(9):2856-2864.
  26. Qingguo Li#, Jitao Wu, Ping Wei, Ye Xu, Changhua Zhuo, Yuwei Wang, Dawei Li, Sanjun Cai*. Overexpression of forkhead Box C2 promotes tumor metastasis and indicates poor prognosis in colon cancer via regulating epithelial-mesenchymal transition. Am J Cancer Res, 2015 May 15; 5(6):2022-34.
  27. Changhua Zhuo#, Qingguo Li#, Yuchen Wu, Yiwei Li, Jia Nie, Dawei Li, Junjie Peng, Peng Lian, Bin Li, Guoxiang Cai, Xinxiang Li*Sanjun Cai*. LINE-1 hypomethylation in normal colon mucosa is associated with poor survival in Chinese patients with sporadic colon cancer. Oncotarget, 2015 Sep 15; 6(27):23820-36.
  28. Yu-Wei Wang#, Li-Yong Huang#, Cheng-Li Song, Chang-Hua Zhuo, De-Bing Shi, Guo-Xiang Cai, Ye Xu, San-Jun Cai*, Xin-Xiang Li*. Laparoscopic vs open abdominoperineal resection in the multimodality management of low rectal cancers. World J Gastroenterol, 2015 Sep 21; 21(35):10174-83.
  29. Xiaoji Ma#, Xinxiang Li#, Linghui Xu, Debing Shi, Tong Tong, Dan Huang, Ying Ding, Sanjun Cai*, Junjie Peng*. Characteristics and Prognostic Significance of Preoperative Magnetic Resonance Imaging-Assessed Circumferential Margin in Rectal Cancer. Gastroenterol Res Pract, 2015:410150.
  30. Xin-Xiang Li#, Lei Liang#, Li-Yong Huang, Sanjun Cai*. Standard chemotherapy with cetuximab for treatment of colorectal cancer. World J Gastroenterol, 2015 Jun 14; 21(22):7022-35.
 
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