专职PI
梁琳慧 副研究员
副研究员,博士
E-mail: lianglinhui@fudan.edu.cn
 

  2006年毕业于中国协和医科大学血液学研究所,获内科学博士。2006年至2012年在上海市肿瘤研究所癌基因及相关基因国家重点实验室工作,2013年至今在复旦大学生物医学研究院/复旦大学附属肿瘤医院工作。主要研究方向为非编码RNA在肿瘤发生发展中的作用和分子机制。近5年曾主持项目包括国家“十一五”重大专项子课题一项,上海市自然科学基金一项,上海市卫生局青年基金一项,上海市青年科技启明星人才计划一项。目前承担的课题有国家“十二五”重大专项子课题一项,国家自然科学基金一项,卫生局新优青人才计划一项,并作为课题骨干参与973国家重大研究计划一项。近5年发表论著24篇,主要发表在Nature Cell Biology、Hepatology、Oncogene等国际著名专业期刊上。相关研究内容获教育部自然科学奖二等奖一项(排名第二),上海医学奖二等奖一项(排名第二)。


研究领域:

  消化系统恶性肿瘤发病的分子机制研究,主要是非编码RNA在肿瘤发生与转移中的功能、作用机制和临床转化。


代表性论著:

  1. Lian Junwei, Jing Ying, Dong Qiongzhu, Huan Lin, Chen Di, Bao Chunyang, Wang Qifeng, Zhao Fangyu, Li Jinjun, Yao Ming, Qin Lunxiu, Liang Linhui*, He Xianghuo*. miR-192, a prognostic indicator, targets the SLC39A6/SNAIL pathway to reduce tumor metastasis in human hepatocellular carcinoma. Oncotarget, 2016; 7(3):2672-2683.
  2. Huan Lin, Bao Chunyang, Chen Di, Li Yan, Lian Junwei, Ding Jie, Huang Shenglin, Liang Linhui*, He Xianghuo*. MiR-127-5p targets the biliverdin reductase B/NF-kappaB pathway to suppress cell growth in hepatocellular carcinoma cells.Cancer Science, 2016 Mar; 107(3):258-66.
  3. Yu zhang, jian yao, lin huan, junwei lian, chunyang bao, yan li, chao ge, jinjun li, ming ya, linhui liang*, xianghuo he*. GNAI3 inhibits tumor cell migration and invasion and is posttranscriptionally regulated by miR-222 in hepatocellular carcinoma. Cancer Letters, 2015; 356:978-984.
  4. Ke G, Liang L, Yang JM, Huang X, Han D, Huang S, Zhao Y, Zha R, He X, Wu X. MiR-181a confers resistance of cervical cancer to radiation therapy through targeting the pro-apoptotic PRKCD gene. Oncogene, 2013; 32(25):3019-27.
  5. Zheng B#, Liang L#, Huang S, Zha R, Liu L, Jia D, Tian Q, Wang Q, Wang C, Long Z, Zhou Y, Cao X, Du C, Shi Y, He X. MicroRNA-409 suppresses tumour cell invasion and metastasis by directly targeting radixin in gastric cancers.Oncogene, 2012; 31(42):4509-16.
  6. Yao J#, Liang L#, Zhang Y, Ding J, Tian Q, Li JJ, He XH. GNAI1 Suppresses Tumor Cell Migration and Invasion and is Post-Transcriptionally Regulated by Mir-320a/c/d in Hepatocellular Carcinoma. Cancer Biology and medicine, 2012; 9(4):234-241.
  7. Tian Q, Liang L, Ding J, Zha R, Shi H, Wang Q, Huang S, Guo W, Ge C, Chen T, Li J, He X. MicroRNA-550a acts as a pro-metastatic gene and directly targets cytoplasmic polyadenylation element-binding protein 4 in hepatocellular carcinoma.PLoS One, 2012; 7(11):e48958.
  8. Ying Q#, Liang L#, Guo W, Zha R, Tian Q, Huang S, Yao J, Ding J, Bao M, Ge C, Yao M, Li J, He X. Hypoxia-inducible microRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma. Hepatology, 2011; 54(6): 2064-2075.
  9. Liang L, He X. Macro-management of microRNAs in cell cycle progression of tumor cells and its implications in anti-cancer therapy. Acta Pharmacol Sin, 2011; 32(11):1311-20.
  10. Zheng B, Liang L, Wang C, Huang S, Cao X, Zha R, Liu L, Jia D, Tian Q, Wu J, Ye Y, Wang Q, Long Z, Zhou Y, Du C, He X, Shi Y. MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer. Clin Cancer Res, 2011; 17(24):7574-83.
  11. Liang L, Wong CM, Ying Q, Fan DN, Huang S, Ding J, Yao J, Yan M, Li J, Yao M, Ng IO, He X. MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2. Hepatology, 2010; 52(5):1731-1740.
  12. Yao J, Liang L, Huang S, Ding J, Tan N, Zhao Y, Yan M, Ge C, Zhang Z, Chen T, Wan D, Yao M, Li J, Gu J, He X. MicroRNA-30d Promotes Tumor Invasion and Metastasis by Targeting Galphai2 in Hepatocellular Carcinoma. Hepatology, 2010; 51(3):846-856.
 
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