专职PI
胡欣 副研究员
副研究员,博士
E-mail: xinhu.nlorg@gmail.com
 

  2008年从癌基因及相关基因国家重点实验室(上海市肿瘤研究所)获复旦大学博士学位。2009至2012年在美国德州大学M.D.安德森癌症中心分子遗传系从事博士后研究。2012年进入复旦大学附属肿瘤医院/肿瘤研究所工作,现为副研究员,硕士生导师;担任肿瘤研究所所长助理、上海市乳腺肿瘤重点实验室秘书等职务。主要从事乳腺癌肿瘤基因组学、肿瘤耐药机制研究、DNA损伤和修复以及高通量文库筛选方向的研究,主要研究成果发表在Cell、Nature Commun、Hepatology、Cancer Res、JBC  等国际期刊。


研究领域:

  1.乳腺癌肿瘤基因组学;
  2.肿瘤耐药机制研究;
  3.DNA损伤修复研究;
  4.高通量文库筛选。


代表性论著:

  1. Zheng YZ, Xue MZ, Shen HJ, Li XG, Ma D, Gong Y, Liu YR, Qiao F, Xie HY, Lian B, Sun WL, Zhao HY, Yao L, Zuo WJ, Li DQ, Wang P, Hu X*, Shao ZM*. PHF5A Epigenetically Inhibits Apoptosis to Promote Breast Cancer Progression. Cancer Res, 2018 (Accepted)
  2. Chen L#, Yang L#, Yao L#, Kuang XY, Zuo WJ, Li S, Qiao F, Liu YR, Cao ZG, Zhou SL, Zhou XY, Yang WT, Shi JX, Huang W, Hu X*, Shao ZM*. Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients. Nat Commun, 2018 Apr 10; 9(1):1357.
  3. Lang GT#, Shi JX#, Hu X#, Zhang CH#, Shan L, Song CG, Zhuang ZG, Cao AY, Ling H, Yu KD, Li S, Sun MH, Zhou XY*, Huang W*, Shao ZM*. The spectrum of BRCA mutations and characteristics of BRCA-associated breast cancers in China: Screening of 2,991 patients and 1,043 controls by next-generation sequencing. Int J Cancer, 2017 Jul 1; 141(1):129-142.
  4. Kuang XY#, Jiang HS#, Li K, Zheng YZ, Liu YR, Qiao F, Li S, Hu X*, Shao ZM*. The phosphorylation-specific association of STMN1 with GRP78 promotes breast cancer metastasis. Cancer Lett, 2016 Jul 0; 377(1):87-96.(F1000)
  5. Shen H#, Xu W#, Guo R, Rong B, Gu L, Wang Z, He C, Zheng L, Hu X, Hu Z, Shao ZM, Yang P, Wu F, Shi YG, Shi Y*, Lan F*. Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex. Cell, 2016 Apr 7; 165(2):331-42.
  6. Ye FG#, Song CG#*, Cao ZG, Xia C, Chen DN, Chen L, Li S, Qiao F, Ling H, Yao L, Hu X*, Shao ZM. Cytidine deaminase axis modulated by miR-484 differentially regulates cell proliferation and chemoresistance in breast cancer. Cancer Res, 2015 Apr 1; 75(7):1504-15.
  7. Zheng YZ#, Cao ZG#, Hu X*, Shao ZM*. The endoplasmic reticulum stress markers GRP78 and CHOP predict disease-free survival and responsiveness to chemotherapy in breast cancer. Breast Cancer Research and Treatment, 2014 Jun; 145(2):349-58.
  8. Hu X, Paul A, Wang B. Rap80 Protein Recruitment to DNA Double-strand Breaks Requires Binding to Both Small Ubiquitin-like Modifier (SUMO) and Ubiquitin Conjugates. J Biol Chem, 2012 Jul 20; 287(30):25510-9.
  9. Hu X, Kim J, Castillo A, Huang M, Liu J, Wang B*. NBA1/Merit40 and BRE interaction is required for the integrity of two distinct deubiqutinating enzyme BRCC36 containing complexes. J Biol Chem, 2011 Apr 1; 286(13):11734-45.
  10. Hu X#, Zhao Y#, He X, Li J, Wang T, Zhou W, Wan D, Wang H, Gu J*. Ciliary neurotrophic factor receptor alpha subunit-modulated multiple downstream signaling pathways in hepatic cancer cell lines and their biological implications. Hepatology, 2008 Apr; 47(4):1298-308.
 
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