专职PI
胡欣 副研究员
副研究员,博士
E-mail: xinhu.nlorg@gmail.com
 

  2008年从癌基因及相关基因国家重点实验室(上海市肿瘤研究所)获复旦大学博士学位。2009至2012年在美国德州大学M.D.安德森癌症中心分子遗传系从事博士后研究。2012年进入复旦大学上海市肿瘤医院/乳腺癌研究所工作,现为副研究员,硕士生导师。主要从事乳腺癌肿瘤基因组学、DNA损伤和修复、肿瘤细胞信号转导以及小分子靶向性药物耐药方向的研究,并具有海外研究背景和工业界药物研发经验,在Hepatology、Cancer Research、Clinical Cancer Research、Oncotarget、Journal of Biological Chemistry等国际期刊上发表SCI论文32篇,其中第一作者或者通讯作者16篇。


研究领域:

  1.乳腺癌肿瘤基因组学;
  2.肿瘤耐药机制研究;
  3.DNA损伤修复研究;
  4.高通量文库筛选。


代表性论著:

  1. Ling H, Li S, Wu Y, Zheng YZ, Qiao F, Yao L, Cao ZG, Ye FG, Wu J, Hu X*, Wang B*, Shao ZM*. Genetic evaluation of BRCA1 associated a complex genes with triple-negative breast cancer susceptibility in chinese women. Oncotarget, 2016 Feb 1; doi: 10.18632/oncotarget.7112. 
  2. Ye FG, Song CG, Cao ZG, Xia C, Chen DN, Chen L, Li S, Qiao F, Ling H, Yao L, Hu X*, Shao ZM*. Cytidine deaminase axis modulated by miR-484 differentially regulates cell proliferation and chemoresistance in breast cancer.Cancer Res, 2015 Apr 1; 75(7):1504-15. 
  3. Kuang XY, Chen L, Zhang ZJ, Liu YR, Zheng YZ, Ling H, Qiao F, Li S, Hu X*, Shao ZM*. Stathmin and phospho-stathmin protein signature is associated with survival outcomes of breast cancer patients. OncoTarget, 2015 Sep 8; 6(26):22227-38.
  4. Zheng YZ, Wang L, Hu X*, Shao ZM*. Effect of tumor size on breast cancer-specific survival stratified by joint hormone receptor status in a SEER population-based study. OncoTarget, 2015 Sep 8; 6(26):22985-95.
  5. Zheng YZ, Cao ZG, Hu X*, Shao ZM*. The endoplasmic reticulum stress markers GRP78 and CHOP predict disease-free survival and responsiveness to chemotherapy in breast cancer. Breast Cancer Research and Treatment, 2014 Jun; 145(2):349-58.
  6. Wang L, Yao L, Zheng YZ, Xu Q, Liu XP, Hu X*, Wang P*, Shao ZM*. Expression of autophagy-related proteins ATG5 and FIP200 predicts favorable disease-free survival in patients with breast cancer. Biochem Biophys Res Commun, 2015 Feb 14; pii: S0006-291X(15)00255-7. 
  7. He M, Hu X*, Chen L, Cao AY, Yu KD, Shi TY, Kuang XY, Shi WB, Ling H, Li S, Qiao F, Yao L, Wei QY, Di GH, Shao ZM*. A recessive variant of XRCC4 predisposes to non-BRCA1/2 breast cancer in chinese women and impairs the DNA damage response via dysregulated nuclear localization. OncoTarget, 2014 Dec 15; 5(23):12218-32.
  8. Hu X#, Paul A, Wang B. Rap80 Protein Recruitment to DNA Double-strand Breaks Requires Binding to Both Small Ubiquitin-like Modifier (SUMO) and Ubiquitin Conjugates. J Biol Chem, 2012 Jul 20; 287(30):25510-9.
  9. Hu X#, Kim J, Castillo A, Huang M, Liu J, Wang B. NBA1/Merit40 and BRE interaction is requiredfor the integrity of two distinct deubiqutinating enzyme BRCC36 containing complexes. J Biol Che, 2011 Apr 1; 286(13):11734-45.
  10. Hu X#, Zhao Y#, He X, Li J, Wang T, Zhou W, Wan D, Wang H, Gu J. Ciliary neurotrophic factor receptor alpha subunit-modulated multiple downstream signaling pathways in hepatic cancer cell lines and their biological implications.Hepatology, 2008 Apr; 47(4):1298-308.
 
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