专职PI
贾立军 研究员
研究员,博士生导师
E-mail: Ljjia@fudan.edu.cn
 

  贾立军博士,复旦大学附属肿瘤医院肿瘤研究所研究员,博士生导师。长期从事“抗肿瘤分子靶点发现和靶向药物研发”等研究工作。迄今在J Natl Cancer Inst (JNCI)、J Clin Invest(JCI)、Autophagy、Cancer Res、Clin Cancer Res、Cell Death Differ、Mol Cell Proteomics、Cell Death Disease和J Biol Chem等期刊发表SCI文章40篇、获邀参编英文专著4部。主持国家自然科学基金(81572340,81372196,31071204,30500637,81172092)、国家重点基础研究发展规划(2012CB910302,课题负责)、上海市卫生局A类重点项目 (2010012)、上海市“浦江人才”资助计划(12PJ1400600)、上海高校特聘教授(东方学者)和上海市“曙光人才”(14SG07)资助计划等科研项目。获邀担任国家自然科学基金委员会医学科学领域学科评审专家、国家自然科学基金重点国际(地区)合作研究项目评审组专家、中国抗癌协会肿瘤病因学专业委员会委员、中华医学科技奖评审委员会委员、高等学校自然科学奖和技术发明奖评审专家、三个国际学术期刊编委和二十余种学术期刊(Gastroenterology、Cancer Research、Journal of Hepatology和Oncogene等)审稿专家。荣获上海高校特聘教授(东方学者)、上海市曙光人才和上海市浦江人才等荣誉称号。


研究领域:

  1.Neddylation修饰通路调控肿瘤发生发展机制及其靶向治疗;
  2.针对CRL/SCF E3泛素连接酶超家族的抗肿瘤分子靶点鉴定;
  3.肿瘤靶向性细菌介导的实体瘤免疫治疗:效应与机制。


研究团队:



代表性论著:

  1. Binghong Liu#, Yanan Jiang#, Tiangeng Dong, Ming Zhao, Jianfu Wu, Lihui Li, Yiwei Chu, Shangyang She, Hu Zhao, Robert M Hoffman, Lijun Jia*. Blockage of autophagy pathway enhances Salmonella tumor-targeting. Oncotarget, 2016; 7(16):22873- 22882.
  2. Ping Chen#, Tao Hu#, Yupei Liang, Pei Li, Xiaoyu Chen, Jingyang Zhang, Yangcheng Ma, Qianyun Hao, Jinwu Wang, Ping Zhang, Yanmei Zhang, Hu Zhao, Shengli Yang, Jinha Yu, Lak Shin Jeong, Hui Qi, Meng Yang, Robert M. Hoffman, Ziming Dong*, Lijun Jia*. Neddylation Inhibition Activates the Extrinsic Apoptosis Pathway through ATF4-CHOP-DR5 Axis in Human Esophageal Cancer Cells. Clinical Cancer Research, 2016 Mar 16. pii: clincanres.2254.2015. [Epub ahead of print]
  3. Dong T#, Yi T, Yang M, Lin S, Li W, Xu X, Hu J, Jia L, Hong X, Niu W*. Cooperation of alpha-galactosylceramide loaded tumor cells and TLR9 agonists induce potent anti-tumor responses in a murine colon cancer model. Biochem J, 2016 Jan 1; 473(1):7-19.
  4. Junfeng Xu#, Lihui Li, Guangyang Yu, Wantao Ying, Qiang Gao, Wenjuan Zhang, Xianyu Li, Chen Ding, Yanan Jiang, Dongping Wei, Shengzhong Duan, Qunying Lei, Peng Li, Tieliu Shi, Xiaohong Qian, Jun Qin, Lijun Jia*. Neddylation-Cullin 2-RBX1 E3 ligase axis targets tumor suppressor RhoB for degradation in liver cancer. Mol Cell Proteomics, 2015 Mar; 14(3):499-509.
  5. Zhang WC#, Zheng XJ#, Du LJ#, Sun JY, Shen ZX, Shi C, Sun S, Zhang Z, Chen XQ, Qin M, Liu X, Tao J, Jia L, Fan HY, Zhou B, Yu Y, Ying H, Hui L, Liu X, Yi X, Liu X, Zhang L, Duan SZ*. High salt primes a specific activation state of macrophages, M (Na). Cell Research, 2015 Aug; 25(8):893-910.
  6. Ping Chen#, Tao Hu,Yupei Liang, Yongfu Pan, Yanan Jiang, Chunjie Li, Ping Zhang, Dongping Wei, Pei Li, Lak Shin Jeong, Yiwei Chu, Hui Qi, Meng Yang, Robert M. Hoffman, Ziming Dong, Lijun Jia*. Synergistic inhibition of autophagy and neddylation pathways as a novel therapeutic approach for targeting liver cancer. Oncotarget, 2015 Apr 20; 6(11):9002-17.
  7. Wei Hua#, Chunjie Li#, Zixiao Yang, Lihui Li, Yanan Jiang, Guangyang Yu, Wei Zhu, Zhengyan Liu, Shengzhong Duan, Yiwei Chu, Meng Yang, Yanmei Zhang, Ying Mao, and Lijun Jia*. Suppression of glioblastoma by targeting the overactivated protein neddylation pathway. Neuro-Oncology, 2015 Oct; 17(10):1333-43.
  8. Yanchun Wang#, Zhongguang Luo#, Yongfu Pan, Weige Wang, Xiaoyan Zhou, Lak Shin Jeong, Yiwei Chu, Jie Liu, Lijun Jia*. Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells. Cancer Biology and Therapy, 2015; 16:420-9.
  9. Lihui Li#, Mingsong Wang, Guangyang Yu, Ping Chen, Hui Li, Dongping Wei, Ji Zhu, Li Xie, Huixun Jia, Jieyi Shi, Chunjie Li, Wantong Yao, Yanchun Wang, Qiang Gao, Lak Shin Jeong, Hyuk Woo Lee, Jinha Yu, Fengqing Hu, Ju Mei, Ping Wang, Yiwei Chu, Hui Qi, Meng Yang, Ziming Dong, Yi Sun, Robert M. Hoffman, Lijun Jia*. Overactivated neddylation pathway as a therapeutic target in lung cancer. Journal of the National Cancer Institute (JNCI), 2014 May 22; 106(6):dju083.
  10. Qiang Gao#, Guang-Yang Yu#, Jie-Yi Shi#, Li-Hui Li#, Wen-Juan Zhang, Zhi-Chao Wang, Liu-Xiao Yang, Meng Duan, Hu Zhao, Xiao-Ying Wang, Jian Zhou, Shuang-Jian Qiu, Lak Shin Jeong, Li-Jun Jia*, Jia Fan*. Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target. Oncotarget, 2014; 5:7820-32. (Co-corresponding author)
  11. Wan-Tong Yao#, Jian-Fu Wu, Guang-Yang Yu, Rui Wang, Kai Wang, Li-Hui Li, Ping Chen, Ya-Nan Jiang, He Cheng ,Hyuk Woo Lee, Jinha Yu, Hui Qi, Xian-Jun Yu, Ping Wang, Yi-Wei Chu, Meng Yang, Zi-Chun Hua, Hao-Qiang Ying, Robert M. Hoffman, Lak Shin Jeong, Li-Jun Jia*. Suppression of tumor angiogenesis by targeting protein neddylation pathway. Cell Death & Disease, 2014 Feb 13; 5:e1059.
  12. Hua Li#, Mingjia Tan, Lijun Jia,Guoan Chen, Yongchao Zhao, Lili Zhao, Dafydd Thomas, David Beer, Yi Sun. Inactivation of Sag/Rbx2/Roc2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis. Journal of Clinical Investigation, 2014; 124:835-46.
  13. Dongqin Yang#, Lihui Li, Hui Liu, Lijun Wu, Zhongguang Luo, Haixia Li, Shimin Zheng, Haifeng Gao , Yiwei Chu ,Yi Sun, Jie Liu, Lijun Jia*. Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells. Cell Death & Differentiation, 2013; 20:235-47.
  14. Ding C#, Jiang J#, Wei J, Liu W, Zhang W, Liu M, Fu T, Lu T, Song L, Ying W, Chang C, Zhang Y, Ma J, Wei L, Malovannaya A, Jia L, Zhen B, Wang Y, He F, Qian X, Qin J*. A fast workflow for identification and quantification of proteomes. Mol Cell Proteomics, 2013; 12: 2370-80.
  15. Dongqin Yang#, Yongchao Zhao, Jie Liu, Yi Sun, Lijun Jia*. Protective autophagy induced by RBX1/ROC1 knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis . Autophagy, 2012; 8:1856-8.
  16. Zhongguang Luo#, Guangyang Yu, Hyuk Woo Lee, Lihui Li, Lingyan Wang, Dongqin Yang, Yongfu Pan, Chan Ding, Jing Qian, Lijun Wu, Yiwei Chu, Jing Yi, Xiangdong Wang, Yi Sun, Lak Shin Jeong, Jie Liu, Lijun Jia*. An NEDD8-Activating Enzyme inhibitor MLN4924 suppresses the growth of hepatocellular carcinoma cells by modulating autophagy and apoptosis. Cancer Research, 2012; 72:3360-3371.
  17. Zhongguang Luo#, Yongfu Pan, Lak Shin Jeong, Jie Liu, Lijun Jia*. Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells. Autophagy, 2012; 8:1677-1679.
  18. Yongchao Zhao#, Xiufang Xiong, Lijun Jia,Yi Sun*. Targeting Cullin-RING ligases by MLN4924 induces autophagy by modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell Death & Disease, 2012 Sep 6; 3:e386.
  19. Mingjia Tan#, Yongchao Zhao, Sun-Jung Kim,Margaret Liu, Lijun Jia,Thomas Saunders, Yuan Zhu, Yi Sun*. SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF-1 for degradation. Developmental Cell, 2011; 21:1-15.
  20. Lijun Jia#*, Jeremy Bickel, Jiaxue Wu, Meredith Morgan, Hua Li, Jie Yang, Xiaochun Yu, Raymond Chan*, Yi Sun*. RBX1 E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins. JBC, 2011; 286:3379-86.
  21. Lijun Jia#*, Hua Li#, Yi Sun*. Induction of p21-dependent senescence by a NAE inhibitor, MLN4924 as a mechanism of growth suppression. Neoplasia, 2011; 13:563-569.
  22. Lijun Jia#, Yi Sun*. SCF E3 ubiquitin ligase as anticancer target. Current Cancer Drug Targets, 2011; 11:347-56.  
  23. Lijun Jia#, Jie Yang, Xinbao Hao, Min Zheng, Hongbin He, Xiufang Xiong, Liang Xu, Yi Sun*. Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anti-cancer and radio-sensitizing target. Clin Cancer Res, 2010; 16:814-24.
  24. Lijun Jia#, Maria S. Soengas, Yi Sun*. ROC1/RBX1 E3 ubiquitin ligase silencing suppresses tumor cell growth via sequential induction of G2/M arrest, apoptosis, and senescence. Cancer Research, 2009; 69:4974-82.
  25. Zhen Wang#, Min Zheng, Zhichuan Li, Ruiguo Li, Lijun Jia,Xiufang Xiong, Noel Southall, Shaomeng Wang, Christopher P. Austin, Wei Zheng, Zijian Xie, Yi Sun*. Cardiac glycosides inhibit p53 protein synthesis via activating Src/MAPK signaling pathways. Cancer Research, 2009; 69:6556-64.
  26. Chen G#, Wei DP#, Jia LJ*#, Tang B, Shu L, Zhang K, Xu Y, Gao J, Huang XF, Jiang WH, Hu QG, Huang Y, Wu Q, Sun ZH, Zhang JF, Hua ZC*. Oral delivery of tumor-targeting Salmonella exhibits promising therapeutic efficacy and low toxicity. Cancer Sci, 2009; 100: 2437-43.
  27. Lijun Jia#, Yi Sun*. SCF F-box protein FBXO31 and FBX4 in the regulation of cyclin D1 degradation upon DNA damage. Pigment Cell Melanoma Res, 2009; 22:518-9.
  28. Lijun Jia#, Yi Sun*. RBX1/ROC1-SCF E3 ubiquitin ligase is required for mouse embryogenesis and cancer cell survival. Cell Division, 2009; 4:1-5.
  29. Lijun Jia#, Genggeng Yu, Michael Wang*. Lysosome-dependent degradation of Notch3. International Journal of Biochemistry & Cell Biology, 2009; 41:2594-8.
  30. Yanmei Zhang#, Lijun Jia#, Soo Jun Lee, Michael Wang*. Conserved Notch3 signal peptide inhibits cytoplasmic interactions. Biochem Bioph Res Co, 2007; 355:245-51.
  31. Lijun Jia#, Dongping Wei, Qiming Sun, Guanghui Jin, Shufeng Li, Yan Huang, Zichun Hua*. Tumor-targeting Salmonella typhimurium improves cyclophosphamide chemotherapy at maximum tolerated dose and low-dose metronomic regimens in a murine melanoma model. Int J Cancer, 2007; 121:666-74.
  32. Lijun Jia#, Dongping Wei, Qiming Sun, Yan Huang, Zichun Hua*. Oral delivery of tumor-targeting Salmonella for cancer therapy in murine tumor models. Cancer Science, 2007; 98:1107-12.
  33. Lijun Jia#, Hanmei Xu, Dingyuan Ma, Qingang Hu, Xiaofeng Huang, Wenhui Jiang, Shufeng Li, Kunzhi Jia, Qilai Huang, Zichun Hua*. Enhanced Therapeutic Effect by Combination of Tumor-Targeting Salmonella and Endostatin in Murine Melanoma Model. Cancer Biology & Therapy, 2005; 4:840-5.
 
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